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MetabolomicsMaternal steroids during pregnancy and their associations with ambient air pollution and temperature during preconception and early gestational periods
Hormones play critical roles in facilitating pregnancy progression and the onset of parturition. Several classes of environmental contaminants, including fine particulate matter (PM2.5) and ambient temperature, have been shown to alter hormone biosynthesis or activity. However, epidemiolo...
2024-06-27 | MTBLS2245 | MetaboLights
TranscriptomicsPho regulon modulation of Enterohemorrhagic *Escherichia coli* O157:H7 virulence factors
In E. coli the phosphate homeostasis is regulated by the Pst system and the two-component system PhoB/R. Pathogens like E. coli O157:H7 are responsible for many outbreaks and can be found and survive in poor inorganic phosphate (Pi) environments. To understand global EHEC O157:H7 EDL933 strain respo...
ORGANISM(S): Escherichia coli 
2014-03-15 | E-GEOD-50529 | biostudies-arrayexpress
TranscriptomicsGene Expression in Peripheral Blood Leucocytes in Monozygotic Twins Discordant for Chronic Fatigue
Background. Chronic fatiguing illness remains a poorly understood syndrome of unknown pathogenesis. We attempted to identify biomarkers for chronic fatiguing illness using microarrays to query the transcriptome in peripheral blood leukocytes. Methods. Cases were 44 individuals who were clinically ev...
ORGANISM(S): Homo sapiens 
2009-05-12 | E-GEOD-16059 | biostudies-arrayexpress
MetabolomicsMetabolomics Insights in Early Childhood Caries
Dental caries is characterized by a dysbiotic shift at the biofilm-tooth surface interface, yet comprehensive biochemical characterizations of the biofilm are scant. We used metabolomics to identify biochemical features of the supragingival biofilm associated with early childhood caries (ECC) preval...
2021-01-29 | MTBLS2215 | MetaboLights
Transcriptomics17b-Trenbolone study
We investigated the genomic transcriptional response of female fathead minnows (Pimephales promelas) to an acute (4 day) exposure to 0.1 or 1.0 µg/L of, 17β-trenbolone (TB), the active metabolite of an anabolic androgenic steroid used as a growth promoter in cattle and a contaminant of concern in ...
ORGANISM(S): Pimephales promelas 
2010-05-14 | E-GEOD-12904 | biostudies-arrayexpress
UnknownDeficiency of the Fanconi anemia E2 ubiqitin conjugase UBE2T only partially abrogates Alu-mediated recombination in a new model of homology dependent recombination.
Not available
S-EPMC6468168 | biostudies-literature
UnknownAssessment of whole brain white matter integrity in youths and young adults with a family history of substance-use disorders.
Not available
S-EPMC4206569 | biostudies-literature
TranscriptomicsTranscription profiling of human lung fibroblasts (HLF) treated with Cr(VI) a carcingogen in the presence of PTP to investigate the effect of protein tyrosine phosphatases inhibition on changes in gene expression
Although the consequences of genotoxic injury include cell cycle arrest and apoptosis, cell survival responses after genotoxic injury can produce intrinsic death-resistance and contribute to the development of a transformed phenotype. Protein tyrosine phosphatases (PTPs) are integral components of k...
ORGANISM(S): Homo sapiens 
2009-01-13 | E-GEOD-12205 | biostudies-arrayexpress
UnknownUnified Analysis of Secondary Traits in Case-Control Association Studies.
Not available
S-EPMC3881430 | biostudies-literature
UnknownEstimating odds ratios in genome scans: an approximate conditional likelihood approach.
Not available
S-EPMC2665019 | biostudies-literature
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