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TranscriptomicsGene expression profiling in the liver of 3-month old mice with a mutant Wrn protein treated with vitamin C compared to the liver of 3-month old untreated mice with a mutant Wrn protein.
Werner syndrome (WS) is a rare disorder characterized by the premature onset of a number of age-related diseases. The gene responsible for WS is believed to be involved in different aspects of transcription, replication, and/or DNA repair. We generated a mouse model with a deletion in the helicase d...
ORGANISM(S): Mus musculus 
2015-05-09 | E-GEOD-68688 | biostudies-arrayexpress
ProteomicsDiscovery and characterization of a novel WRN inhibitor
Discovery and characterization of a novel WRN inhibitor
ORGANISM(S): Homo sapiens (Human) 
2024-01-31 | PXD044202 | Pride
Cancer Wrn Inhibitor Msi 
GenomicsIdiomarina sp. WRN-38
Idiomarina sp. WRN-38 Genome sequencing and assembly
PRJNA309018 | ENA
GenomicsGuyparkeria sp. WRN-7
Guyparkeria sp. WRN-7 Genome sequencing and assembly
PRJNA309017 | ENA
ProteomicsAnalysis of WRN protein interactome
Our focus of research, the Werner protein, is one of disease-associated RecQ helicases. Its deficiency results in the Werner syndrome (WS), characterized by accelerated rate of mutation and the organism's inability to resolve a variety of genome-damaging events. Mutations in the WRN gene (also refer...
ORGANISM(S): Homo sapiens (Human) 
2022-02-28 | PXD000812 | Pride
Wrn Proteomics Human Aging 
TranscriptomicsTranscription profiling of mouse liver from wild type and Wrn mutant animals with or without vitamin C treatment
Werner syndrome (WS) is a rare disorder characterized by the premature onset of a number of age-related diseases. The gene responsible for WS is believed to be involved in different aspects of transcription, replication, and/or DNA repair. We generated a mouse model with a deletion in the helicase d...
ORGANISM(S): Mus musculus 
2009-09-11 | E-GEOD-14549 | biostudies-arrayexpress
GenomicsMicrobulbifer flavimaris strain:WRN-8
Microbulbifer flavimaris strain:WRN-8 Genome sequencing and assembly
PRJNA309016 | ENA
GenomicsTrAEL-seq for WRN inhibitors
TrAEL-seq for WRN inhibitors
PRJNA1064407 | ENA
GenomicsExpression data of WRN-K577M
Expression data of WRN-K577M
PRJNA612802 | ENA
TranscriptomicsDifferential expression of genes in liver of mice with a nonfunctional helicase domain of the Wrn protein treated with resveratrol compared to untreated wild type mice.
Werner syndrome (WS) is a rare disorder characterized by the premature onset of a number of age-related diseases. The gene responsible for WS is believed to be involved in different aspects of transcription, replication, and/or DNA repair. We generated a mouse model with a deletion in the helicase d...
ORGANISM(S): Mus musculus 
2010-10-08 | E-GEOD-21431 | biostudies-arrayexpress
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