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ProteomicsProteogenomic Characterization Reveals Tumorigenesis and Progression of Lung Adenocarcinoma Manifested as Subsolid Nodules
Lung adenocarcinoma (LUAD) radiologically displayed as subsolid nodules (SSNs) is prevalent. However, precise clinical management of SSNs requires thorough understanding of its tumorigenesis and progression. Here, we analyzed 66 LUAD displayed as SSNs covering 3 histological stages including adenoca...
ORGANISM(S): Homo sapiens (Human) 
2025-02-10 | PXD046637 | Pride
Lung adenocarcinoma  proteomic Phosphoproteomic  glycoproteomic 
ProteomicsMTCH2 modulates CPT1 activity to regulate lipid metabolism of adipocytes
MTCH2 is a protein localized in the outer membrane of mitochondria. It belongs to the solute carrier 25 family, but its substrates or transporter function remains unknown. Previous research links MTCH2 to apoptosis induction, and Alzheimer’s disease, mitochondrial metabolism and dynamics, and MTCH2 ...
ORGANISM(S): Mus musculus (Mouse) 
2025-07-20 | PXD054881 | Pride
Mouse Brown adipocytes Dia 
MetabolomicsAcupuncture Synergized With Bortezomib Improves Survival of Multiple Myeloma Mice via Decreasing Metabolic Ornithine
Multiple myeloma (MM) is a hematological malignancy worldwide in urgent need for novel therapeutic strategies. Since Velcade (bortezomib) was approved for the treatment of relapsed/refractory MM in 2003, we have seen considerable improvement in extending MM patient survival. However, most patients a...
2022-02-21 | MTBLS3487 | MetaboLights
UnknownIntermittent Theta Burst Stimulation (iTBS) as an Optimal Treatment for Schizophrenia Risk Decision: an ERSP Study.
Not available
S-EPMC8143028 | biostudies-literature
UnknownVisualizing designer quantum states in stable macrocycle quantum corrals.
Not available
S-EPMC8501084 | biostudies-literature
ProteomicsComparative proteomics of fresh sperm and frozen sperm collected by electric stimulation method and Artificial vagina method
This progect included TMT-based proteomics and PRM proteomics. The study aimed to we aimed to investigate the differential impact of rectal probe electrostimulation and artificial vagina semen collection methods on the quality and the freezing tolerance of goat sperm.
ORGANISM(S): Capra Hircus 
2023-11-29 | PXD047354 |
ProteomicsComparison of affinity enrichment methods for O-GlcNAc proteomics
In this work, by using the lysates of PANC-1 (a pancreatic cancer cell line), we provided a head-to-head comparison of three affinity enrichment methods/materials (i.e., antibody, lectin AANL6, and an OGA mutant) for O-GlcNAc proteomics. The enrichment was performed before or after high-pH HPLC frac...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) Saccharomyces Cerevisiae (ncbitaxon:4932) 
2024-04-23 | MSV000094604 | MassIVE
TranscriptomicsOptimized siRNAs with a minimal off-target effect facilitate the screening of essential genes in cancer cells
siRNAs with dN are a promising and easy approach to characterize essential genes by minimizing the off-target effect in cancer cells. mRNA profiles of HCT 116 cells after the transfection of siRNAs or blank control by deep sequencing, using HiSeq 2000
ORGANISM(S): Homo sapiens 
2015-07-01 | E-GEOD-62968 | biostudies-arrayexpress
ProteomicsStudy on goat sperm by quantitative proteomics technology
The summary file contains summary information for all the raw files processed with a single MaxQuant run. The summary information consists of some MaxQuant parameters, information of the raw file contents, and statistics on the peak detection. Based on this file a quick overview can be gathered on t...
ORGANISM(S): Capra Hircus 
2023-06-22 | PXD043267 |
ProteomicsProteomic analysis of radioiodine-refractory differentiated thyroid cancer
Radioiodine refractory differentiated thyroid cancer (RR-DTC) is the main factor affecting the overall survival rate of thyroid cancer clinically. In order to investigate its underlying molecular mechanism of pathogenesis with the hope to explore novel therapeutic targets for clinical treatment, we ...
ORGANISM(S): Homo Sapiens 
2022-11-05 | PXD037968 |
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