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ProteomicsSelective Regulation of Macrophage Lipid Metabolism via Nanomaterials’ Surface Chemistry
Understanding the interfacial structure between nanomaterials and lipoproteins is crucial for gaining profound insights into how nanomaterials impact lipoprotein structure and interfere with lipid metabolism. In this study, we employed graphene oxide (GO) nanosheets (NSs) with precisely controlled s...
ORGANISM(S): Homo sapiens (Human) 
2025-05-06 | PXD044475 | Pride
Human plasma Low density lipoprotein Lc-ms Lipid metabolism Graphene oxide Surface hydrophilicity 
MetabolomicsLimited nutrient availability in the tumor microenvironment renders pancreatic tumors sensitive to allosteric IDH1 inhibitors

Nutrient-deprived conditions in the tumor microenvironment (TME) restrain cancer cell viability due to increased free radicals and reduced energy production. In pancreatic cancer cells, a cytosolic metabolic enzyme, wild-type isocitrate dehydrogenase 1 (wtIDH1), enables the adaptation to these co...

2022-04-29 | MTBLS4722 | MetaboLights
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