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TranscriptomicsTranscription profiling of human TLR2/1 stimulated human monocytes with the Mycobacterium tuberculosis derived 19kDa lipopeptide reveals Toll-like receptor triggering of a vitamin D-mediated human antimicrobial response
In innate immune responses, activation of Toll-like receptors (TLRs) triggers direct antimicrobial activity against intracellular bacteria, which in murine, but not human, monocytes and macrophages is mediated principally by nitric oxide. We report here that TLR activation of human macrophages up-re...
ORGANISM(S): Homo sapiens 
2008-06-17 | E-GEOD-8921 | biostudies-arrayexpress
TranscriptomicsmRNA-Seq of head tissue from Drosophila mojavensis
We sequenced mRNA from head tissue of females and male of Drosophila mojavensis to identify genes differentially expressed between the sexes and sex-specific alternative splicing events. For data usage terms and conditions, please refer to http://www.genome.gov/27528022 and http://www.genome.gov/Pa...
ORGANISM(S): Drosophila mojavensis 
2010-04-11 | E-GEOD-20882 | biostudies-arrayexpress
TranscriptomicsmRNA and sRNA Transcriptomes Reveal Insights into Dynamic Homoeolog Regulation for Allopolyploid Heterosis in Nascent Hexaploid Wheat
Nascent allohexaploid wheat may represent the initial genetic state for the evolution and domestication of common wheat, which arose by combining the AB genomes of tetraploid Triticum turgidum with the D genome from Aegilops tauschii and out-competed its parents in growth vigor and adaptability. To ...
ORGANISM(S): Triticum dicoccon 
2014-10-20 | E-GEOD-56587 | biostudies-arrayexpress
ProteomicsMycobacterium tuberculosis produces D-serine under hypoxia to limit CD8+ T cell-dependent immunity in mice
Interferon (IFN)-γ-producing CD8+ T cells are involved in control of Mycobacterium tuberculosis (Mtb) infection, in part by promoting antimicrobial activities of macrophages. Whether Mtb counters these responses, particularly during the hypoxic conditions that arise within granulomas during infectio...
ORGANISM(S): Mycobacterium tuberculosis OFXR-32 
2024-08-10 | PXD050258 | Pride
Mycobacterium tuberculosis  d-serine  rv0884c  wdr24  mtorc1  cd8+ t cell 
TranscriptomicsActinomycin D-induced mitochondrial stress targets PML during NPM1c-AML therapy
Microarrays transcriptomic data analyses from acute myeloid leukemia cell line OCI-AML2 and primary acute myeloid leukemia cells treated with actinomycin D.
ORGANISM(S): Homo sapiens 
2021-05-10 | E-MTAB-10397 | biostudies-arrayexpress
TranscriptomicsmRNA-Seq of head tissue from Drosophila melanogaster
We sequenced mRNA from head tissue of females and male of Drosophila melanogaster to identify genes differentially expressed between the sexes and sex-specific alternative splicing events. For data usage terms and conditions, please refer to http://www.genome.gov/27528022 and http://www.genome.gov/...
ORGANISM(S): Drosophila melanogaster 
2010-04-08 | E-GEOD-20348 | biostudies-arrayexpress
ProteomicsIDH1-mutant metabolite D-2-Hydroxyglutarate inhibits proliferation and sensitizes glioma to Temozolomide via down-regulating ITGB4/PI3K/AKT
The effects of D-2HG on U251 cells by conducting a proteomic analysis
ORGANISM(S): Homo Sapiens 
PXD052264 |
TranscriptomicsSalt/NaCl stress in Desulfovibrio vulgaris Hildenborough
This set of microarray data was used to investigate the effects of D. vulgaris adaptation to excess NaCl. Keywords: stress response, one time point (the mid-log phase for both control and treated cells) Comparison of cells treated with 250 Salt:NaCl to untreated cells at times of mid-log phase min.
ORGANISM(S): Desulfovibrio vulgaris str. Hildenborough 
2010-04-11 | E-GEOD-14343 | biostudies-arrayexpress
ProteomicsNUDCD3 deficiency disrupts V(D)J recombination to cause SCID/Omenn syndrome
Inborn errors of T cell development present a pediatric emergency in which timely curative therapy is informed by molecular diagnosis. In 9 affected patients across 3 consanguineous kindreds, we detected homozygosity for a single deleterious missense variant in the gene NudC domain containing 3 (NUD...
ORGANISM(S): Homo sapiens (Human) 
2024-09-27 | PXD035840 | Pride
Pulldown Nudcd3 Proteomics Omenn syndrome 
TranscriptomicspH stress in Desulfovibrio vulgaris Hildenborough
Using data from microarray experiments, we investigated the effects of excess NaCl on D. vulgaris. Keywords: stress response, time course Comparison of cells treated with pH10 pH to untreated cells at times of 0,120,240,30,60 min.
ORGANISM(S): Desulfovibrio vulgaris str. Hildenborough 
2007-08-31 | E-GEOD-8197 | biostudies-arrayexpress
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