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DAPA improved pancreatic beta-cell function in diabetic mice by inhibiting NLRP3-Caspase-1 signaling, enhancing insulin vesicle fusion, and modulating mitochondrial homeostasis, indicating its potential as a novel treatment for diabetes.
ORGANISM(S): Mus Musculus 
2024-08-06 | PXD054615 |
Here, we presented a streamlined workflow to measure abundant AMG510 modified peptides including that of KRAS/G12C by direct profiling, and a pan-AMG510 antibody peptide IP workflow to profile less abundant AMG510 off-targets.
ORGANISM(S): Homo Sapiens 
2023-01-11 | PXD029449 |
The HEK293T cells transiently expressing Flag-tagged empty vector or Flag-NRDE2-WT were lysed in NETN buffer (10 mM Tris-HCl [pH 8.0], 100 mM NaCl, 1 mM EDTA, and 0.5% NP-40) and immunoprecipitated with anti-Flag M2 agarose (M8823; Sigma-Aldrich, MO, USA). After washing four times with the high stri...
ORGANISM(S): Homo Sapiens 
2024-03-31 | PXD051117 |
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