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ProteomicsNUDCD3 deficiency disrupts V(D)J recombination to cause SCID/Omenn syndrome
Inborn errors of T cell development present a pediatric emergency in which timely curative therapy is informed by molecular diagnosis. In 9 affected patients across 3 consanguineous kindreds, we detected homozygosity for a single deleterious missense variant in the gene NudC domain containing 3 (NUD...
ORGANISM(S): Homo sapiens (Human) 
2024-09-27 | PXD035840 | Pride
Pulldown Nudcd3 Proteomics Omenn syndrome 
ProteomicsRBM39 organizes an m⁶A-dependent silencing complex to degrade Tat mRNA and maintain HIV-1 latency
Given the pivotal role of Tat in HIV-1 latency, we performed RNA pull-down assays in latently HIV-1-infected J-Lat 10.6 cells using biotinylated RNA probes (including a control RNA probe and a Tat-specific RNA probe) . Cell lysates were incubated with streptavidin agarose resin pre-bound to Tat RNA ...
ORGANISM(S): Homo sapiens (Human) 
2025-10-31 | PXD064834 | Pride
Lc/ms Tat Rip J-lat 10.6 
UnknownUtilizing Polymer Micelle to Control Dye J-aggregation and Enhance Its Theranostic Capability.
Not available
S-EPMC6906732 | biostudies-literature
UnknownConcomitant SK current activation and sodium current inhibition cause J wave syndrome.
Not available
S-EPMC6302939 | biostudies-literature
UnknowndPRLR causes differences in immune responses between early and late feathering chickens after ALV-J infection.
Not available
S-EPMC8742939 | biostudies-literature
UnknownThe colonic macrophage transcription factor RBP-J orchestrates intestinal immunity against bacterial pathogens.
Not available
S-EPMC7144519 | biostudies-literature
UnknownCCL4 participates in the reprogramming of glucose metabolism induced by ALV-J infection in chicken macrophages.
Not available
S-EPMC10272584 | biostudies-literature
UnknownMolecular Mechanism of V(D)J Recombination from Synaptic RAG1-RAG2 Complex Structures.
Not available
S-EPMC4690471 | biostudies-literature
UnknownThe C-terminal helices of heat shock protein 70 are essential for J-domain binding and ATPase activation.
Not available
S-EPMC3285371 | biostudies-literature
UnknownIsolation and characterization of avian leukosis virus subgroup J associated with hemangioma and myelocytoma in layer chickens in China.
Not available
S-EPMC9555167 | biostudies-literature
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