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GenomicsNext Generation Sequencing Facilitates Quantitative Analysis of effect of knockdown of GATA2 on AR binding sites
Purpose: Next-generation sequencing (NGS) has revolutionized systems-based analysis of cellular pathways. The goals of this study are to compare AR binding activity in LNCaP cells with and without knockdown of GATA2. Methods: LNCaP cells between passage number 32-34 were used for assay. Cells are tr...
ORGANISM(S): Homo sapiens 
2014-01-21 | E-GEOD-52725 | biostudies-arrayexpress
Genomics5-hydroxymethylcytosine-mediated epigenetic dynamics during neurodevelopment and aging [5hmC Capture and Seq]
DNA methylation dynamics influence brain function and are altered in neurological disorders. 5-hydroxymethylcytosine (5-hmC), a DNA base derived from 5-methylcytosine (5mC) accounts for ~40% of modified cytosine in brain, and has been implicated in DNA methylation-related plasticity. Here we map 5-h...
ORGANISM(S): Mus musculus 
2011-10-30 | E-GEOD-32050 | biostudies-arrayexpress
Genomicsena-DATASET-dkfz_b062-21-02-2018-14:40:33:479-591 - samples
This dataset contains whole exome sequencing data from 24 patients. The Agilent SureSelect Human All Exon 50-Mb target enrichment kit was used to capture all human exons for deep sequencing. For each patient a tumour and control sample has been sequenced on a Illumina HiSeq2000 instrument in paired-...
EGAD00001003973 | EGA
TranscriptomicsDynamic nature of epigenetic patterns observed during the Mars 520-d mission simulation
Interplanetary human spaceflight represents a formidable medical challenge, but also provides a unique platform for investigating human adaptation to extreme environmental changes. Understanding the long-term effects of isolation has relevance in a range of scenarios and it is well recognized that a...
ORGANISM(S): Homo sapiens 
2015-01-14 | E-GEOD-64950 | biostudies-arrayexpress
UnknownecDNA hubs drive cooperative intermolecular oncogene expression.
Not available
S-EPMC9126690 | biostudies-literature
TranscriptomicsTriplication of a 21q22 region contributes to B cell transformation through HMGN1 overexpression and loss of histone H3 Lys27 trimethylation [RNA-Seq]
Down syndrome (DS) confers a 20-fold increased risk of B cell acute lymphoblastic leukemia (ALL), yet the mechanisms underlying this association are undefined.  We show that triplication of only 31 genes orthologous to the putative DS Critical Region (DSCR) on chr.21q22 is sufficient to promote B ce...
ORGANISM(S): Mus musculus 
2014-04-20 | E-GEOD-48553 | biostudies-arrayexpress
UnknownIdentification of proteins associated with type 2 diabetes risk in diverse racial and ethnic populations.
Not available
S-EPMC11963907 | biostudies-literature
UnknownExome-Derived Adiponectin-Associated Variants Implicate Obesity and Lipid Biology.
Not available
S-EPMC6732522 | biostudies-literature
UnknownExome-Derived Adiponectin-Associated Variants Implicate Obesity and Lipid Biology.
Not available
S-EPMC6612516 | biostudies-literature
UnknownGenetic Studies of Leptin Concentrations Implicate Leptin in the Regulation of Early Adiposity.
Not available
S-EPMC7679778 | biostudies-literature
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