Sort   by:  
 Page size 
UnknownIntegration of Germline Pharmacogenetics Into a Tumor Sequencing Program.
Not available
S-EPMC7434089 | biostudies-literature
TranscriptomicsKnockout of Vdac1 activates the HIF signaling pathway and induces tumor development in vivo by promoting vascular remodeling and inflammation
Mitochondria are subcellular organelles that are more than just the powerhouse of cells, they also dictate if a cell dies or survives. The mitochondrial outer-membrane voltage-dependent anion channel 1 (VDAC1) has been shown to play a crucial role in metabolism and apoptosis, however its involvement...
ORGANISM(S): Mus musculus 
2015-04-27 | E-GEOD-63247 | biostudies-arrayexpress
UnknownPatient-driven discovery and post-clinical validation of NTRK3 fusion as an acquired resistance mechanism to selpercatinib in RET fusion-positive lung cancer.
Not available
S-EPMC8119360 | biostudies-literature
TranscriptomicsGene expression profiles of MCF7 with CARM1 knocked down
The goal of this study is to identify ERalpha-target genes affected by knocking down of the histone arginine methyltransferase CARM1 in MCF7 breast cancer cells. The roles of CARM1 in ERalpha+ breast cancer was not well characterized. Therefore, we created a Dox inducible CARM1 knockingdown MCF7 cel...
ORGANISM(S): Homo sapiens 
2011-06-01 | E-GEOD-26259 | biostudies-arrayexpress
TranscriptomicsLong Noncoding RNA MALAT1 Controls Cell Cycle Progression by Regulating the Expression of Oncogenic Transcription Factor B-MYB
The long noncoding MALAT1 RNA is upregulated in cancer tissues and its elevated expression is associated with hyper-proliferation, but the underlying mechanism is poorly understood. We demonstrate that MALAT1 levels are regulated during normal cell cycle progression. Genome-wide transcriptome analys...
ORGANISM(S): Homo sapiens 
2014-05-16 | E-GEOD-44240 | biostudies-arrayexpress
TranscriptomicsRNA-seq of human epithelium-only colonic and small intestinal organoids derived from intestinal resections, biopsy specimens and cryopreserved crypts
Patient-derived gastrointestinal epithelium-only organoids from the small and large intestine, also referred to as colonoids and enteroids, were generated as part of the development of an on-going organoid biobank at the Michigan Medicine Translational Tissue Modeling Laboratory (TTML) (www.UmichTTM...
ORGANISM(S): Homo sapiens 
2020-07-24 | E-MTAB-9339 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of rat kidney progenitor tissue from embryo at E13
In this study we compared genes expressed in the unbudded portion of the Wolffian duct with the isolated ureteric bud to find genes novel to early kidney development. We used the Affymetrix Rat Genome 230 2.0 Array to compare the unbudded tissues with the budded samples. We used microarrays to find...
ORGANISM(S): Rattus norvegicus 
2009-12-19 | E-GEOD-18260 | biostudies-arrayexpress
TranscriptomicsSelective demethylation and altered gene expression are associated with ICF Syndrome in human induced pluripotent stem cells and mesenchymal stem cells
Immunodeficiency, Centromeric Instability, and Facial Anomalies Type I (ICF1) Syndrome is a rare genetic disease caused by mutations in DNMT3B, a de novo DNA methyltransferase. However, the molecular basis of how DNMT3B-deficiency leads to ICF1 pathogenesis is unclear. Induced pluripotent stem cell ...
ORGANISM(S): Homo sapiens 
2014-11-17 | E-GEOD-46030 | biostudies-arrayexpress
UnknownTherapeutic Impact of Cytoreductive Surgery and Irradiation of Posterior Fossa Ependymoma in the Molecular Era: A Retrospective Multicohort Analysis.
Not available
S-EPMC4962737 | biostudies-literature
TranscriptomicsStromal factors SDF1alpha, sFRP1 and VEGFD induce dopaminergic neuron differentiation of human pluripotent stem cells
The identified stromal factors SDF1alpha, sFRP1 and VEGFD induce dopaminergic neuron differentiation of human pluripotent stem cells. Human embryonic stem cell (hESC)-derived dopaminergic (DA) neurons are potentially useful for treating Parkinson’s disease (PD) through cell replacement therapy. Gen...
ORGANISM(S): Mus musculus 
2012-06-24 | E-GEOD-20503 | biostudies-arrayexpress
Sort   by:  
 Page size