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GenomicsIdentification of Transcription Factor LIN-15B::GFP Binding Regions in L3
modENCODE_submission_2610 This submission comes from a modENCODE project of Michael Snyder. For full list of modENCODE projects, see http://www.genome.gov/26524648 Project Goal: We are identifying the DNA binding sites for 300 transcription factors in C. elegans. Each transcription factor gene is ta...
ORGANISM(S): Caenorhabditis elegans 
2011-02-18 | E-GEOD-25802 | biostudies-arrayexpress
GenomicsIdentification of Transcription Factor LIN-13::GFP Binding Regions in Embryos
modENCODE_submission_2613 This submission comes from a modENCODE project of Michael Snyder. For full list of modENCODE projects, see http://www.genome.gov/26524648 Project Goal: We are identifying the DNA binding sites for 300 transcription factors in C. elegans. Each transcription factor gene is ta...
ORGANISM(S): Caenorhabditis elegans 
2011-02-18 | E-GEOD-25804 | biostudies-arrayexpress
TranscriptomicsTCF7 is a key regulator of the switch of self-renewal and differentiation in a multipotential hematopoietic cell line
A critical problem in biology is understanding how cells choose between self-renewal and differentiation. To generate a comprehensive view of the mechanisms controlling early hematopoietic precursor self-renewal and differentiation, we used systems-based approaches and murine EML multipotential hema...
ORGANISM(S): Mus musculus 
2012-03-29 | E-GEOD-30068 | biostudies-arrayexpress
GenomicsIdentification of Transcription Factor LIN-39::GFP Binding Regions in L3
modENCODE_submission_2432 This submission comes from a modENCODE project of Michael Snyder. For full list of modENCODE projects, see http://www.genome.gov/26524648 Project Goal: We are identifying the DNA binding sites for 300 transcription factors in C. elegans. Each transcription factor gene is ta...
ORGANISM(S): Caenorhabditis elegans 
2011-02-18 | E-GEOD-25785 | biostudies-arrayexpress
GenomicsTCF7 is a key regulator of the switch of self-renewal and differentiation in a multipotential hematopoietic cell line
A critical problem in biology is understanding how cells choose between self-renewal and differentiation. To generate a comprehensive view of the mechanisms controlling early hematopoietic precursor self-renewal and differentiation, we used systems-based approaches and murine EML multipotential hema...
ORGANISM(S): Mus musculus 
2012-03-29 | E-GEOD-31221 | biostudies-arrayexpress
UnknownButyrolactone-I, an efficient α-glucosidase inhibitor, improves type 2 diabetes with potent TNF-α-lowering properties through modulating gut microbiota in db/db mice.
Not available
S-EPMC6902678 | biostudies-literature
TranscriptomicsGene expression profiling of novel antigen presenting cells (APC) inducing pathogenic T helper cells of lupus
In lupus autoimmunity, pathogenic IgG autoantibodies that fix complement and bind FcGammaR on inflammatory cells, are produced with help from T helper (Th1 and Th17) cells specific for peptides from nucleosomes of apoptotic cells; and these Th cells also infiltrate vital organs (1-9). Macrophages (...
ORGANISM(S): Mus musculus 
2012-06-20 | E-GEOD-36284 | biostudies-arrayexpress
UnknownPore-Forming Protein LIN-24 Enhances Starvation Resilience in Caenorhabditis elegans by Modulating Lipid Metabolism and Mitochondrial Dynamics.
Not available
S-EPMC11860826 | biostudies-literature
TranscriptomicsGene expression profiling in BCR-ABL expressing LSCs and BCR-ABL-BLK expressing LSCs
Using BCR-ABL-induced chronic myeloid leukemia (CML) as a disease model for leukemia stem cells (LSCs), we showed that BCR-ABL down-regulates the B lymphoid kinase (Blk) gene in leukemia stem cells in CML mice and that Blk functions as a tumor suppressor in LSCs and suppresses LSC function. Inhibiti...
ORGANISM(S): Mus musculus 
2012-07-05 | E-GEOD-36096 | biostudies-arrayexpress
TranscriptomicsGene expression profiling in WT and Alox15-/- HSCs
To understand the underlying mechanism by which Alox15 gene is required by HSCs, we performed a comparative DNA microarray analysis using total RNA isolated from wild type Lin-Sca-1+c-Kit+, Alox5-/- Lin-Sca-1+c-Kit+. The result was validated by quantitative real-time PCR analysis of wild type Lin-Sc...
ORGANISM(S): Mus musculus 
2011-05-17 | E-GEOD-29348 | biostudies-arrayexpress
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