Sort   by:  
 Page size 
ProteomicsTKI-resistant T790M EGFR Mutation Rewired EGFR Translocation Routes through Switching Interactome in Non-Small Cell Lung Cancer
Epidermal growth factor receptor (EGFR) harboring active mutations, Del19 and L858R, are most common oncogenic mutations in in non-small cell lung cancer (NSCLC) patients. The preferred treatment at first line is tyrosine kinase inhibitor (TKI) administration while the TKI-resistance usually develop...
ORGANISM(S): Homo Sapiens (human) 
2023-05-31 | PXD034228 | JPOST Repository
ProteomicsUniversal and robust bacterial phosphoproteomics analysis
In present work, we established a simple and robust protocol for universal bacterial phosphoproteomic analysis underlying the rationale of methanol-based LLE protein extraction and cleanup. Using the SDS lysis as the conventional protocol control, we carefully evaluated the efficiency of protein ext...
ORGANISM(S): Escherichia Coli Cellular Organisms 
2025-08-04 | PXD055159 | JPOST Repository
ProteomicsQuantification Quality Control Emerges as A Crucial Factor to Enhance Single Cell Proteomics Data Analysis
Mass spectrometry (MS)-based single-cell proteomics (SCP) provides us the opportunity to unbiasedly explore biological variability within cells without the limitation of antibody availability. This field is rapidly developed with the main focuses on instrument advancement, sample preparation refinem...
ORGANISM(S): Homo Sapiens (human) 
2025-01-09 | PXD048595 | JPOST Repository
ProteomicsComparative Proteomics Reveals Prolonged Corneal Preservation Impaired Ocular Surface Immunity Accompanied with Fibrosis in Human Stroma
Cornea transplantation is a widely performed procedure globally. However, storing donor corneas for extended periods in Optisol-GS storage medium at 4 ℃ can lead to reduced endothelial cell viability, causing severe stromal edema and opacification. This negatively impacts transplantation success. Th...
ORGANISM(S): Homo Sapiens (human) 
2024-09-29 | PXD045907 | JPOST Repository
ProteomicsBenchmarking differential expression, imputation and quantification methods for proteomics data
Data analysis is a critical part of quantitative proteomics studies in interpreting biological questions. Numerous computational tools including protein quantification, imputation, and differential expression (DE) analysis were generated in the past decade. However, searching optimized tools is stil...
ORGANISM(S): Homo Sapiens (human) Saccharomyces Cerevisiae (baker's Yeast) Drosophila Melanogaster (fruit Fly) 
2022-11-16 | PXD029891 | JPOST Repository
ProteomicsCold Atmospheric Plasma Jet Activated Medium Promotes Wound Healing through CK2-mediated ERK and AKT signaling pathways
In this study, we aimed to explore the molecular mechanisms of wound healing affected by CAPJ using the parallel MS-based proteome and phosphoproteome. The keratinocyte, HaCaT, was used as cell mode to treat CAPJ indirectly by employing plasma activated medium (PAM) which was culture medium explored...
ORGANISM(S): Homo Sapiens (human) 
2025-02-22 | PXD050065 | JPOST Repository
UnknownPrediction of postoperative infection in elderly using deep learning-based analysis: an observational cohort study.
Not available
S-EPMC10014765 | biostudies-literature
UnknownGuidelines for the use and interpretation of assays for monitoring autophagy (3rd edition).
Not available
S-EPMC4835977 | biostudies-literature
UnknownElective surgery cancellations due to the COVID-19 pandemic: global predictive modelling to inform surgical recovery plans.
Not available
S-EPMC7272903 | biostudies-literature
Sort   by:  
 Page size