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TranscriptomicsTemporal expression of miR-17-92a regulates effector and memory CD8+ T cell differentiation
This SuperSeries is composed of the following subset Series: GSE34216: miRNA signatures of antigen specific CD8+ T cells at different stages of immune response to LCMV infection GSE34217: Expression profile of miR-17-92a-MSCV-IRES-Thy1.1 transduced P14 CD8+ T cells Refer to individual Series
ORGANISM(S): Mus musculus 
2012-06-04 | E-GEOD-34218 | biostudies-arrayexpress
TranscriptomicsExpression profile of miR-17-92a-MSCV-IRES-Thy1.1 transduced P14 CD8+ T cells
During acute viral infections, effector CD8+ T cells differentiate into memory precursors or short-lived terminal effectors. miR-17-92a over-expression skews CD8+ effector cells to the terminal differentiation. We used microarray to identify the genes that are differentially expressed caused by miR-...
ORGANISM(S): Mus musculus 
2012-06-04 | E-GEOD-34217 | biostudies-arrayexpress
TranscriptomicsExpression data from virus-specific mouse Th1 and Tfh CD4 T cell subsets after LCMV infection
CD4 T follicular helper (Tfh) cells provide the required signals to B cells for germinal center reactions that are necessary for longlived antibody responses. However, it remains unclear whether there are CD4+ memory T cells committed to the Tfh lineage after antigen clearance. Using adoptive transf...
ORGANISM(S): Mus musculus 
2013-04-22 | E-GEOD-43863 | biostudies-arrayexpress
TranscriptomicsmiRNA signatures of antigen specific CD8+ T cells at different stages of immune response to LCMV infection
miRNAs play an important role in regulating CD8+ T cell response. We used the microarray approach to profile the miRNA signatures of naïve, day 5 effector, day 8 effector, and memory CD8+ T cells. We identified a miRNA signature associated with rapidly proliferating effector CD8+ T cells. CD8+ T cel...
ORGANISM(S): Mus musculus 
2012-06-04 | E-GEOD-34216 | biostudies-arrayexpress
TranscriptomicsTCF1 is required for the differentiation of T follicular helper (TFH) cells during viral infections
TFH and Th1 cells generated after viral or intracellular bacterial infections are critical for the control of infections and the development of immunological memories. However, the mechanisms that govern the choice of activated CD4 T cells to the two alternative fates remain unclear. Here, we found ...
ORGANISM(S): Mus musculus 
2015-09-18 | E-GEOD-65660 | biostudies-arrayexpress
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