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ProteomicsA CHKA–PML autophagy checkpoint enables tumors to evade glutamine starvation
CHKA phosphorylates PML at Tyr339 to promote its cytoplasmic localization; cytoplasmic PML then induces WIPI2 SUMOylation at Lys281/283, blocking HUWE1-mediated degradation. Stabilized WIPI2 enhances autophagic flux and supports tumor cell survival under metabolic stress.
ORGANISM(S): Homo Sapiens 
2026-03-03 | PXD075116 |
ProteomicsProteomics comparison of protein changes in two well-established animal pain models of chronic pain using wild-type and Nav1.8 knockout mice
Isobaric tags for relative and absolute quantitation -based proteomics analysis was performed to profile changes in the abundance of spinal cord proteins in two well-established animal pain models of chronic pain using wild-type and Nav1.8 knockout mice
ORGANISM(S): Mus <genus> 
2023-05-24 | PXD042455 |
ProteomicsProteomics and liquid biopsy characterization of human EMT-related metastasis in colorectal cancer
Tumor cells undergo epithelial-mesenchymal transition (EMT), however, there is a room of disagreement in role of EMT heterogeneity to colorectal cancer metastasis (mCRC) evolution. To uncover new EMT-related metastasis proteins and pathways, we addressed the EMT status in colorectal cancer liver met...
ORGANISM(S): Homo Sapiens 
2022-05-09 | PXD033788 |
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