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MetabolomicsCD73 inhibitor AB680 suppresses glioblastoma in mice by inhibiting purine metabolism and promoting P2RY12<sup>+</sup> microglia transformation.
CD73 (ecto-5'-nucleotidase) is a metabolic immune checkpoint that dephosphorylates AMP to produce adenosine. Adenosine plays a pivotal role in immunosuppressive tumor microenvironment (TME) through adenosine receptors expressed on various immune cells. AB680, a specific CD73 inhibitor, is currently ...
2025-08-04 | MTBLS11084 | MetaboLights
ProteomicsProteome of norfloxacin-resistant Edwardsiella tarda
we propagate norfloxacin-resistant strain, LTB4-R, through sequential propagations of norfloxacin-sensitive LTB4 in TSB broth medium with norfloxacin. LTB4-R had 128-fold minimum inhibitory concentrations (MIC) of LTB4-S. To profile the differential protein expression between LTB4-R and LTB4-S, tand...
ORGANISM(S): Edwardsiella Tarda 
2023-06-06 | PXD042752 |
UnknownDetection of an anti-angina therapeutic module in the effective population treated by a multi-target drug Danhong injection: a randomized trial.
Not available
S-EPMC8410855 | biostudies-literature
UnknownGuidelines for the use and interpretation of assays for monitoring autophagy (3rd edition).
Not available
S-EPMC4835977 | biostudies-literature
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