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ProteomicsN-glycosylation of AXL receptor tyrosine kinase regulates its stability, phosphorylation and oncogenic function
AXL, a receptor tyrosine kinase implicated in tumor progression, undergoes post-translational modifications that regulate its activity and stability. In this study, we have analyzed AXL immunoprecipitated from cell lines by liquid chromatography–tandem mass spectrometry (LC-MS/MS)-based glycoproteom...
ORGANISM(S): Homo sapiens (Human) 
2026-06-15 | PXD071027 | Pride
Receptor tyrosine kinase Phosphorylation Axl N-glycosylation Proliferation 
ProteomicsQuantitative proteomic analysis of MCF10A cells with PTEN knockout reveals the regulation of EphA2 expression by PTEN
PTEN, a well-known tumor suppressor, negatively regulates the PI3K-AKT signaling pathway. Its loss is prevalent across various cancer types and leads to significant changes in cellular signaling networks. In this study, we investigate the effects of PTEN loss on both canonical PI3K-AKT and noncanoni...
ORGANISM(S): Homo sapiens (Human) 
2025-12-15 | PXD057520 | Pride
Human breast epithelial cells 
ProteomicsCodon Specific Readthrough as a Mechanism of BRCA2 Restoration in Acquired PARP Inhibitor and Chemotherapy Resistance
Alteration of the gene encoding BRCA2, a protein involved in homologous recombination (HR), by missense or nonsense mutations results in sensitivity of a subset of breast and ovarian cancers to platinating agents and poly(ADP-ribose) polymerase (PARP) inhibitors. Conversely, resistance to these agen...
ORGANISM(S): Homo sapiens (Human) 
2025-10-27 | PXD037989 | Pride
Translational readthrough Ovarian cancer Brca2 
TranscriptomicsAnalysis of the RDR6-dependent small RNA profile in ein5 ski2 in Arabidopsis with biological replications and increased sequencing depth
Post-transcriptional gene silence (PTGS) is employed in plants to shut down transgenes, invading viral genes and a certain group of endogenous genes. Meanwhile, it is not clear how the risk of expansive PTGS from endogenous genes featured by transitive siRNA production is minimized. Here we demonstr...
ORGANISM(S): Arabidopsis thaliana 
2015-04-13 | E-GEOD-57936 | biostudies-arrayexpress
TranscriptomicsAnalysis of the RDR6-dependent ein5 ski2 transcriptome profile in Arabidopsis
Post-transcriptional gene silence (PTGS) is employed in plants to shut down transgenes, invading viral genes and a certain group of endogenous genes. Meanwhile, it is not clear how the risk of expansive PTGS from endogenous genes featured by transitive siRNA production is minimized. Here we demonstr...
ORGANISM(S): Arabidopsis thaliana 
2015-04-13 | E-GEOD-52407 | biostudies-arrayexpress
MetabolomicsFasudil may alleviate alcohol-induced astrocyte damage by modifying lipid metabolism, as determined by metabonomics analysis

Alcohol dependence is a chronic, relapsing encephalopathy characterized by compulsive craving for alcohol, loss of control over alcohol use, and the presence of negative emotions and physical discomfort when alcohol is unavailable. Harmful use of alcohol is one of the greatest risk factors for de...

2023-05-15 | MTBLS5071 | MetaboLights
ProteomicsA Multi-Omic Analysis of Human Naive CD4 T cells
Technological advances in genomics, epigenomics, transcriptomics and proteomics have enabled massively parallel measurements across thousands of genes and gene products. Such high-throughput technologies have been extensively used to carry out genome-wide studies particularly in the context of disea...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2016-04-04 | MSV000079624 | MassIVE
Proteomics,MultiomicsA draft map of the human proteome
The availability of human genome sequence has transformed biomedical research over the past decade. However, an equivalent map for the human proteome with direct measurements of proteins and peptides does not exist yet. Here, we report a draft map of the human proteome based on high resolution Fouri...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2016-02-16 | MSV000079514 | MassIVE
UnknownA multi-omic analysis of human naive CD4+ T cells.
Not available
S-EPMC4636073 | biostudies-literature
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