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GenomicsHomo sapiens
Rescue of Fragile X syndrome by DNA methylation editing of the FMR1 [ChIP-seq]
PRJNA398271 | ENA
TranscriptomicsPromoter directionality is controlled by U1 snRNP and polyadenylation signals
Transcription of the mammalian genome is pervasive, but productive transcription outside of protein-coding genes is limited by unknown mechanisms. In particular, although RNA polymerase II (RNAPII) initiates divergently from most active gene promoters, productive elongation occurs primarily in the s...
ORGANISM(S): Mus musculus 
2013-06-28 | E-GEOD-46433 | biostudies-arrayexpress
ProteomicsRPL3L Mutant Heart Cells LFQ MS.
Mutations in the tissue-specific ribosomal protein RPL3L lead to infant dilated cardiomyopathy. The current project aims to understand the mechanistic details of disease progression using in vivo biopsies from transplanted heart of patient with RPL3L mutations as well as engineered AC16 cell lines t...
ORGANISM(S): Homo sapiens (Human) 
2025-11-15 | PXD066450 | Pride
Ribosome Cardiomyopathy Ac16 Ventricle 
TranscriptomicsComparison of gene expression profiling of human lung at four developmental stages and lung adenocarcioma
It is gradually becoming a new aspect in research to search and explore embryo development for malignant information hidden in tumor cells. In this study, the gene expression profiles for human lungs at four developmental stages and lung adenocarcinoma (ADC) were depicted, respectively. The molecula...
ORGANISM(S): Homo sapiens 
2014-08-25 | E-GEOD-43767 | biostudies-arrayexpress
GenomicsGenome-wide binding of the CRISPR endonuclease Cas9 in mammalian cells
The bacterial CRISPR-Cas9 system has been widely adapted for RNA-guided genome editing and gene regulation in diverse organisms yet its in vivo target specificity is poorly understood. Here we provide the first genome-wide binding maps of nuclease-deactivated Cas9 loaded with guide RNAs in mammalian...
ORGANISM(S): Mus musculus 
2014-04-20 | E-GEOD-54745 | biostudies-arrayexpress
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