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UnknownRandomized, Prospective Evaluation Comparing Intensity of Lymphodepletion Before Adoptive Transfer of Tumor-Infiltrating Lymphocytes for Patients With Metastatic Melanoma.
Not available
S-EPMC4981979 | biostudies-literature
UnknownCurrent Devices in Mitral Valve Replacement and Their Potential Complications.
Not available
S-EPMC7728606 | biostudies-literature
TranscriptomicsTranscription profiling of human AML1-ETO transduced cord blood cells, CD34 selected, compared to normal cord blood cells, CD34 selected
AML1-ETO expression in normal human umbilical cord blood CD34+ cells leads to long-term proliferation of an early self-renewing primitive progenitor cell with multilineage potential and stem cell ability, but these cells do not induce leukemia in immunodeficient mice. This comparative microarray stu...
ORGANISM(S): Homo sapiens 
2008-06-15 | E-GEOD-8023 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human CD34 cells isolated from cord blood or peripheral blood transduced with AML1-ETO or empty vector (MIGR1)
Human CD34 cells isolated from cord blood or peripheral blood transduced with AML1-ETO or empty vector (MIGR1).
ORGANISM(S): Homo sapiens 
2007-08-30 | E-GEOD-2049 | biostudies-arrayexpress
TranscriptomicsTargeting IRAK1 as a therapeutic approach for Myelodysplastic Syndrome
Myelodysplastic Syndromes (MDS) result from expansion of defective hematopoietic stem/progenitor clones. There is an urgent need to develop targeted therapies capable of eliminating the defective MDS clones. We identified that IRAK1, an immune modulating kinase, is overexpressed and hyperactivated i...
ORGANISM(S): Homo sapiens 
2013-04-25 | E-GEOD-46346 | biostudies-arrayexpress
GenomicsGenome-wide DNA methylation events in TMPRSS2:ERG fusion negative prostate cancers implicate an EZH2 dependent mechanism with miRNA-26a hypermethylation.
Prostate cancer is the second most common cancer among men worldwide. Alterations in the DNA methylation pattern can be one of the leading causes for prostate cancer formation. This study is the first high throughput sequencing study investigating genome-wide DNA methylation patterns in a large coho...
ORGANISM(S): Homo sapiens 
2012-12-06 | E-GEOD-35342 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse hematopoetic progenitor cells with Flk12+ Ncad-, Flk12- Ncad+, Flk12+ Ncad+ or Flk12- Ncad- phenotypes
N-cadherin expression level distinguishes reserved versus primed states of hematopoietic stem cells
ORGANISM(S): Mus musculus 
2008-01-04 | E-TABM-404 | biostudies-arrayexpress
TranscriptomicsCytotoxic effects of Bortezomib in Myelodysplastic syndrome/Acute Myeloid Leukemia depend on autophagy-mediated lysosomal degradation of TRAF6 and repression of PSMA1
Bortezomib (VelcadeM-BM-)) is widely used for the treatment of various human cancers, however, its mechanisms of action are not fully understood, particularly in myeloid malignancies. Bortezomib is a selective and reversible inhibitor of the proteasome. Paradoxically, we find that Bortezomib induces...
ORGANISM(S): Homo sapiens 
2012-06-14 | E-GEOD-38519 | biostudies-arrayexpress
TranscriptomicsBinding pattern and chromatin modifications induced by AML1/ETO in human hematopoietic stem/progenitor cells
The AML1/ETO fusion protein, which is present in 10% to 15% of cases of acute myeloid leukemia, is known to repress myeloid differentiation genes through DNA binding and recruitment of chromatin-modifying proteins and transcription factors in target genes. ChIP-chip analysis of human hematopoietic s...
ORGANISM(S): Homo sapiens 
2012-01-18 | E-GEOD-27663 | biostudies-arrayexpress
GenomicsAberrant chromatin acetylation in MLL-AF9 leukemia mediates the response to HDAC inhibition (ChIP-Seq)
We studied the chromatin modification patterns induced by the presence of the MLL-AF9 fusion protein in a model of human hematopoietic stem/progenitor cells (HSPC) transduced with retrovirus expressing MLL-AF9cDNA (HSPC-MA9). Comparative ChIP-seq analysis between HSPC-MA9 and control HSPC, revealed ...
ORGANISM(S): Homo sapiens 
2015-03-01 | E-GEOD-54344 | biostudies-arrayexpress
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