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TranscriptomicsTranscription profiling of human primary hepatocytes treated with transcription factor PPAR agonist Wy14643
Studies in mice have shown that PPARalpha is an important regulator of hepatic lipid metabolism and the acute phase response. However, little information is available on the role of PPARalpha in human liver. Here we set out to compare the function of PPARalpha in mouse and human hepatocytes via anal...
ORGANISM(S): Homo sapiens 
2009-09-25 | E-GEOD-17251 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human and moise primary hepatocytes from 12 donors were treated with PPARI? agonist Wy14643
Studies in mice have shown that PPARα is an important regulator of hepatic lipid metabolism and the acute phase response. However, little information is available on the role of PPARα in human liver. Here we set out to compare the function of PPARα in mouse and human hepatocytes via analysis of t...
ORGANISM(S): Mus musculus 
2009-09-11 | E-GEOD-17254 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human and mouse hepatocytes to perform a comparative analysis of gene regulation by the transcription factor PPARI?_mouse
Studies in mice have shown that PPARα is an important regulator of hepatic lipid metabolism and the acute phase response. However, little information is available on the role of PPARα in human liver. Here we set out to compare the function of PPARα in mouse and human hepatocytes via analysis of t...
ORGANISM(S): Mus musculus 
2009-09-25 | E-GEOD-17250 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse liver from wild-type (129S1/SvImJ) and PPARalpha-null (129S4/SvJae) animals treated with WY14643 vs. controls - 3
PPARα is a ligand-activated transcription factor involved in the regulation of nutrient metabolism and inflammation. Although much is already known about the function of PPARα in hepatic lipid metabolism, many PPARα-dependent pathways and genes have yet to be discovered. In order to obtain an ov...
ORGANISM(S): Mus musculus 
2008-06-16 | E-GEOD-8292 | biostudies-arrayexpress
TranscriptomicsThe impact of PPARα activation on whole genome gene expression in human precision-cut liver slices
Background: Studies in mice have shown that PPARα is an important regulator of lipid metabolism in liver and a key transcription factor involved in the adaptive response to fasting. However, much less is known about the role of PPARα in human liver. Here we set out to study the function of PPARα ...
ORGANISM(S): Homo sapiens 
2015-11-23 | E-GEOD-71731 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse wild-type and PPARI?-null liver treated with the synthetic PPARI? ligand WY14643
PPARα is a ligand-activated transcription factor involved in the regulation of nutrient metabolism and inflammation. Although much is already known about the function of PPARα in hepatic lipid metabolism, many PPARα-dependent pathways and genes have yet to be discovered. In order to obtain an ov...
ORGANISM(S): Mus musculus 
2008-06-16 | E-GEOD-8291 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse PPARalpha knockouse to investigate TPPARalpha-mediated effects of dietary lipids on intestinal barrier gene expression
Background: The selective absorption of nutrients and other food constituents in the small intestine is mediated by a group of transport proteins and metabolic enzymes, often collectively called ‘intestinal barrier proteins’. An important receptor that mediates the effects of dietary lipids on g...
ORGANISM(S): Mus musculus 
2008-06-18 | E-GEOD-9533 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of rat livers with inactivated PPARI
PPARα is a ligand-activated transcription factor involved in the regulation of nutrient metabolism and inflammation. Although much is already known about the function of PPARα in hepatic lipid metabolism, many PPARα-dependent pathways and genes have yet to be discovered. In order to obtain an ov...
ORGANISM(S): Homo sapiens 
2008-06-16 | E-GEOD-8302 | biostudies-arrayexpress
TranscriptomicsDetailed transcriptomics analysis of the effect of dietary fatty acids on gene regulation in the murine heart.
Fatty acids comprise the primary energy source for the heart and are mainly taken up via hydrolysis of circulating triglyceride-rich lipoproteins. While most of the fatty acids entering the cardiomyocyte are oxidized, a small portion is involved in altering gene transcription to modulate cardiometab...
ORGANISM(S): Mus musculus 
2012-02-21 | E-GEOD-30495 | biostudies-arrayexpress
UnknownRegulation of rat hepatic L-pyruvate kinase promoter composition and activity by glucose, n-3 polyunsaturated fatty acids, and peroxisome proliferator-activated receptor-alpha agonist.
Not available
S-EPMC2766394 | biostudies-literature
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