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UnknownFTO genotype and weight loss in diet and lifestyle interventions: a systematic review and meta-analysis.

Background

Studies have suggested that the fat mass and obesity-associated (FTO) genotype is associated with individual variability in weight loss in response to diet/lifestyle interventions, but results are inconsistent.

Objective

We aimed to provide a summary of the literature evalu...
S-EPMC4807705 | biostudies-literature
UnknownMolecular mimicry as a mechanism of viral immune evasion and autoimmunity.
Mimicry of host protein structures, or 'molecular mimicry', is a common mechanism employed by viruses to evade the host's immune system. Short linear amino acid (AA) molecular mimics can elicit cross-reactive antibodies and T cells from the host, but the prevalence of such mimics throughout the huma...
S-EPMC11526117 | biostudies-literature
UnknownMolecular Mimicry as a Mechanism of Viral Immune Evasion and Autoimmunity.
Mimicry of host protein structures ("molecular mimicry") is a common mechanism employed by viruses to evade the host's immune system. To date, studies have primarily evaluated molecular mimicry in the context of full protein structural mimics. However, recent work has demonstrated that short linear ...
S-EPMC10942439 | biostudies-literature
UnknownCost-utility analysis of adding abiraterone acetate plus prednisone/prednisolone to long-term hormone therapy in newly diagnosed advanced prostate cancer in England: Lifetime decision model based on STAMPEDE trial data.
Adding abiraterone acetate (AA) plus prednisolone (P) to standard of care (SOC) improves survival in newly diagnosed advanced prostate cancer (PC) patients starting hormone therapy. Our objective was to determine the value for money to the English National Health Service (NHS) of adding AAP to SOC. ...
S-EPMC9162346 | biostudies-literature
UnknownStage of labor at admission among Ugandan women with a prior cesarean, and its impact on management and delivery outcomes.

Objective

To describe stage of labor at admission among women with a prior cesarean, and examine its impact on intrapartum management and delivery mode.

Methods

In a prospective cohort study, women admitted to Mbarara Regional Referral Hospital, Uganda, for delivery were enrolled betw...
S-EPMC5627950 | biostudies-literature
UnknownA DNA aptamer reveals an allosteric site for inhibition in metallo-β-lactamases.
The hydrolysis of β-lactam antibiotics by β-lactamase enzymes is the most prominent antibiotic resistance mechanism for many pathogenic bacteria. Out of this broad class of enzymes, metallo-β-lactamases are of special clinical interest because of their broad substrate specificities. Several in vitro...
S-EPMC6476477 | biostudies-literature
UnknownNovel imprinted DLK1/GTL2 domain on human chromosome 14 contains motifs that mimic those implicated in IGF2/H19 regulation.
The evolution of genomic imprinting in mammals occurred more than 100 million years ago, and resulted in the formation of genes that are functionally haploid because of parent-of-origin-dependent expression. Despite ample evidence from studies in a number of species suggesting the presence of imprin...
S-EPMC310985 | biostudies-literature
UnknownGenomic imprinting: implications for human disease.
Genomic imprinting refers to an epigenetic marking of genes that results in monoallelic expression. This parent-of-origin dependent phenomenon is a notable exception to the laws of Mendelian genetics. Imprinted genes are intricately involved in fetal and behavioral development. Consequently, abnorma...
S-EPMC1866410 | biostudies-literature
UnknownTissue-specific inactivation of murine M6P/IGF2R.
The mannose 6-phosphate/insulin-like growth factor 2 receptor (M6P/IGF2R) encodes a multifunctional protein involved in lysosomal enzyme trafficking, fetal organogenesis, tumor suppression, and T cell- mediated immunity. M6P/IGF2R is an imprinted gene in mice with expression only from the maternal a...
S-EPMC1851115 | biostudies-literature
UnknownRapid Systematic Screening of Bispecific Antibody Surrogate Geometries for T-Cell Engagement Using DNA Nanotechnology.
Bispecific antibodies (bsAbs) are emerging immune-therapeutics, and many formats exist that differ considerably in structure. However, little systematic data exist about how the spatial organization of their components influences activity, requiring innovative approaches combining empirical and quan...
S-EPMC11529601 | biostudies-literature
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