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MetabolomicsIntegration of metabolomics, genomics and immune phenotypes reveals the causal roles of metabolites in disease

BACKGROUND: Recent studies highlight the role of metabolites in immune diseases, but it remains unknown how much of this effect is driven by genetic and non-genetic host factors.

RESULT: We systematically investigate circulating metabolites in a cohort of 5...

2021-06-14 | MTBLS2633 | MetaboLights
TranscriptomicsCrohn's disease risk variant in GPR65 alters lysosomal function
Using an siRNA screen we identify a role for GPR65 in the defense against intracellular pathogens. Epithelial cells and macrophages lacking GPR65 exhibited impaired clearance of intracellular bacteria as well as an accumulation of aberrant phagosomes and lysosomes. Transcriptional profiling revealed...
ORGANISM(S): Mus musculus 
2016-06-15 | E-GEOD-69445 | biostudies-arrayexpress
UnknownPaneth cell defects in Crohn's disease patients promote dysbiosis.
Not available
S-EPMC5033844 | biostudies-literature
UnknownPAAPPAS community trial protocol: a randomized study of obesity prevention for adolescents combining school with household intervention.
Not available
S-EPMC4989464 | biostudies-literature
UnknownWater-Insoluble Films from Upcycled Babassu Coconut Byproducts: An Alternative Material for Single-Use Oil Sachets.
Not available
S-EPMC12809288 | biostudies-literature
UnknownA novel Ruminococcus gnavus clade enriched in inflammatory bowel disease patients.
Not available
S-EPMC5704459 | biostudies-literature
UnknownNeuropeptides in Rhipicephalus microplus and other hard ticks.
Not available
S-EPMC9477089 | biostudies-literature
MetabolomicsIndustrial by-products as a novel circular source of biocompatible extracellular vesicles

Extracellular vesicles (EVs) constitute an intricate system of molecular exchange that has recently gained tremendous interest. However, sustainable sources of safe biological EVs remain scarce and elusive. In this study we explore and define the use of food industry byproducts (BP) as a circular...

2022-05-17 | MTBLS2801 | MetaboLights
UnknownRuminococcus gnavus, a member of the human gut microbiome associated with Crohn's disease, produces an inflammatory polysaccharide.
Not available
S-EPMC6601261 | biostudies-literature
UnknownEvolution of CCL16 in Glires (Rodentia and Lagomorpha) shows an unusual random pseudogenization pattern.
Not available
S-EPMC6383237 | biostudies-literature
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