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GenomicsMNase digestion-sensitive nucleosomes in Saccharomyces cerevisiae
The structural complexity of nucleosomes underlies their functional versatility. Here we report a new type of complexity – nucleosome fragility, manifested as high sensitivity to micrococcal nuclease, in contrast to the common presumption that nucleosomes are similar in resistance to MNase digestio...
ORGANISM(S): Saccharomyces cerevisiae 
2011-01-24 | E-GEOD-26412 | biostudies-arrayexpress
TranscriptomicsThe Atoh1 targetome in murine postnatal cerebellum
A relatively small number of proneural transcription factors specify a multitude of neural progenitor populations in the developing mammalian brain. Despite their importance, little is known about their targets, cellular processes they regulate, or what genomic sites they occupy in vivo. We used an ...
ORGANISM(S): Mus musculus 
2011-02-08 | E-GEOD-22111 | biostudies-arrayexpress
TranscriptomicsEstrogen deprivation alters epigenetic modifications in breast cancer cells - HOXC10 loss in endocrine resistance
Postmenopausal breast cancer patients benefit from aromatase inhibitors (AIs) that reduce the levels of estrogens critical for the growth of estrogen receptor (ER)-positive tumors. Unfortunately, many tumors are resistant to AI, and we are only beginning to understand the complex mechanisms underly...
ORGANISM(S): Homo sapiens 
2014-05-01 | E-GEOD-39783 | biostudies-arrayexpress
GenomicsAF9 Links Histone Acetylation to DOT1L-Mediated H3K79 Methylation
The recognition of modified histones by “reader” proteins constitutes a key mechanism regulating gene expression in the chromatin context. Compared with the great variety of readers for histone methylation, few protein modules that recognize histone acetylation are known. Here we show that the evolu...
ORGANISM(S): Homo sapiens 
2014-12-11 | E-GEOD-60366 | biostudies-arrayexpress
GenomicsHistone variant H3.3-specific readout of H3K36 trimethylation by ZMYND11 links transcription elongation control to tumour suppression
Recognition of modified histones by “reader” proteins plays a critical role in the regulation of transcription1. H3K36 trimethylation (H3K36me3) is deposited onto the nucleosomes in the transcribed regions following RNA polymerase II (Pol II) elongation. In yeast, this mark in turn recruits epigenet...
ORGANISM(S): Homo sapiens 
2014-02-24 | E-GEOD-48423 | biostudies-arrayexpress
GenomicsSIRT7 is a histone H3 lysine 18 deacetylase that regulates oncogenic transformation
Sirtuin proteins regulate diverse cellular pathways that influence genomic stability, metabolism, and ageing. SIRT7 is a mammalian sirtuin whose biochemical activity, molecular targets, and physiologic functions have been unclear. Here we show that SIRT7 is an NAD+-dependent, histone H3 acetyl-lysin...
ORGANISM(S): Homo sapiens 
2012-05-06 | E-GEOD-28149 | biostudies-arrayexpress
Genomicsde novo DNA Methylation Balances Hematopoietic Stem Cell Self-Renewal and Differentiation
Cytosine methylation is an epigenetic mark usually associated with gene repression. Despite a requirement for de novo DNA methylation for differentiation of embryonic stem cells, its role in somatic stem cells is unknown. Using conditional ablation, we show that loss of either, or both, Dnmt3a or Dn...
ORGANISM(S): Mus musculus 
2011-09-30 | E-GEOD-27322 | biostudies-arrayexpress
GenomicsNSD2 links dimethylation of histone H3 at lysine 36 to oncogenic programming [ChIP]
NSD2 (also named MMSET and WHSC1) is a histone lysine methyltransferase that is implicated in diverse diseases and commonly overexpressed in multiple myeloma due to a recurrent t(4;14) chromosomal translocation. However, the precise catalytic activity of NSD2 is obscure, preventing progress in unde...
ORGANISM(S): Homo sapiens 
2011-11-29 | E-GEOD-29146 | biostudies-arrayexpress
TranscriptomicsNSD2 links dimethylation of histone H3 at lysine 36 to oncogenic programming [RNAi]
NSD2 (also named MMSET and WHSC1) is a histone lysine methyltransferase that is implicated in diverse diseases and commonly overexpressed in multiple myeloma due to a recurrent t(4;14) chromosomal translocation. However, the precise catalytic activity of NSD2 is obscure, preventing progress in unde...
ORGANISM(S): Homo sapiens 
2011-11-29 | E-GEOD-29147 | biostudies-arrayexpress
TranscriptomicsNSD2 links dimethylation of histone H3 at lysine 36 to oncogenic programming [Transduction]
NSD2 (also named MMSET and WHSC1) is a histone lysine methyltransferase that is implicated in diverse diseases and commonly overexpressed in multiple myeloma due to a recurrent t(4;14) chromosomal translocation. However, the precise catalytic activity of NSD2 is obscure, preventing progress in unde...
ORGANISM(S): Mus musculus 
2011-11-29 | E-GEOD-29150 | biostudies-arrayexpress
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