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MetabolomicsBranched-chain ketoacids derived from cancer cells modulate macrophage polarization and metabolic reprogramming

Macrophages are prominent immune cells in the tumor microenvironment that can be educated into pro-tumoral phenotype by tumor cells to favor tumor growth and metastasis. The mechanisms that mediate a mutualistic relationship between tumor cells and macrophages remain poorly characterized. Here, w...

2022-10-03 | MTBLS4497 | MetaboLights
ProteomicsCharacterisation of a novel glycosylated glutathione transferase of Onchocerca ochengi, closest relative of the human river blindness parasite
Filarial nematodes possess glutathione transferases (GSTs), ubiquitous enzymes with potential to detoxify xenobiotic and endogenous substrates, and modulate the host immune system, which may aid worm infection establishment, maintenance and survival in the host. Here we have identified and character...
ORGANISM(S): Onchocerca ochengi (Filarial nematode worm) 
2020-05-26 | PXD013440 | Pride
Glycosylation Onchocerca Prostaglandin synthase Detoxification Glycans Immune modulation Gsts 
ProteomicsPeptidomes of MHC Class I Allotypes Illustrate the Peptide binding Plasticity Leading by Micropolymorphism
The current study provides an opportunity to identify specific MHC I motifs in vitro.The combination of random peptide library,LC-MS/MS and De Novo Sequencing can be an important complement to the identification of MHC I motif.
ORGANISM(S): Sus scrofa domesticus (domestic pig) 
2021-09-09 | PXD019523 | Pride
Mhc class i，random peptide library，lc-ms/ms，de novo sequencing 
UnknownComprehensive profiling of alternative splicing landscape during cold acclimation in tea plant.
Not available
S-EPMC6971990 | biostudies-literature
UnknownDynamic analyses of alternative polyadenylation from RNA-seq reveal a 3'-UTR landscape across seven tumour types.
Not available
S-EPMC4467577 | biostudies-literature
UnknownIntegrated Metabolomic and Transcriptomic Analysis Reveals That Amino Acid Biosynthesis May Determine Differences in Cold-Tolerant and Cold-Sensitive Tea Cultivars.
Not available
S-EPMC9916234 | biostudies-literature
ProteomicsA multi-omics analysis of glioma chemoresistance using a hybrid microphysiological model of glioblastoma
Chemoresistance is a major clinical challenge in management of glioblastoma (GBM) Temozolomide (TMZ) is the chemotherapeutic drug of choice for GBM; however, the therapeutic effect of TMZ is limited due to the development of resistance. Recapitulating GBM chemoresistance in a controlled environment ...
ORGANISM(S): Homo sapiens (Human) 
2025-06-09 | PXD037753 | Pride
A multi-omics analysis of glioma chemoresistance using a hybrid microphysiological model of glioblastoma 
TranscriptomicsAortic arch profiling of Apoe knockout mice
Aortic arch profiling of Apoe-/- mice fed a high fat diet (HFD, Harlan Teklad 88137, 21% fat, 0.15% cholesterol) starting at 8 weeks of age for 8, 16, and 24 weeks. B6 mice fed HFD for 16 weeks starting at 8 weeks of age were used as controls. Apoe-/- mice were fed a high fat diet (HFD, Harlan Tekl...
ORGANISM(S): Mus musculus 
2010-06-22 | E-GEOD-18443 | biostudies-arrayexpress
TranscriptomicsAortic arch profiling of Ldlr knockout mice with human CETP transgene
Aortic arch profiling of Ldlr-/- huCETP transgenic mice fed a low fat, cholesterol-containing western diet (LFWD, 9% fat, 0.15% cholesterol) starting at 8 weeks of age for 4, 8, 12, and 16 weeks. Ldlr-/- huCETP transgenic mice were fed a low fat, cholesterol-containing western diet (LFWD, 9% fat, ...
ORGANISM(S): Mus musculus 
2010-06-22 | E-GEOD-18442 | biostudies-arrayexpress
TranscriptomicsIdentification and validation of causal genes for atherosclerosis in mice
Identification of causal genes for atherosclerosis in a segregating mouse population and validation via single-gene knockout and plaque progression mouse models. This SuperSeries is composed of the following subset Series: GSE18442: Aortic arch profiling of Ldlr knockout mice with human CETP transg...
ORGANISM(S): Mus musculus 
2010-06-23 | E-GEOD-18479 | biostudies-arrayexpress
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