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GenomicsImproved tagmentation-based whole genome bisulfite sequencing for input DNA from less than 100 cells
We improved the tagmentation-based whole genome bisulfite sequencing technology, enabling stable library construction with complexity from minimally 0.5ng of initial genomic DNA, which equals less than 100 cells. This new approach is highly attractive for the complete methylome analysis of very limi...
ORGANISM(S): Oryza sativa 
2014-05-01 | E-GEOD-57062 | biostudies-arrayexpress
GenomicsDirect ChIP-bisulfite sequencing reveals a role of H3K27me3 mediating aberrant hypermethylation of promoter CpG islands in cancer cells
This SuperSeries is composed of the SubSeries listed below. Refer to individual Series
ORGANISM(S): Homo sapiens 
2014-07-01 | E-GEOD-43096 | biostudies-arrayexpress
GenomicsHigh-throughput sequencing of methylated cytosine enriched by modification-dependent restriction endonuclease MspJI
In this study, we combine MspJI digestion and electrophoretic band selection with next generation high-throughput sequencing technology to detect 5-methylcytosines in Arabidopsis genome. By developing a bioinformatics workflow to attribute the CNNR sites recognized by MspJI to the reference genome, ...
ORGANISM(S): Arabidopsis thaliana 
2013-05-01 | E-GEOD-46428 | biostudies-arrayexpress
TranscriptomicsClassification of cancer cell lines using a promoter-targeted liquid hybridization capture-based bisulfite sequencing approach
DNA methylation plays a significant role in assuring cell identity, thus potentiating its application in molecular classification of cancers in respect of tissue origins or clinically and aetiologically distinct subtypes. In this study, we adapted our liquid hybridization capture-based bisulfite seq...
ORGANISM(S): Homo sapiens 
2014-02-19 | E-GEOD-44866 | biostudies-arrayexpress
GenomicsDirect ChIP-bisulfite sequencing reveals a role of H3K27me3 mediating aberrant hypermethylation of promoter CpG islands in cancer cells (ChIP-BS)
The model describing that aberrant CpG island (CGI) methylation leads to transcription repression of tumor suppressor genes and thereby is implicated in tumor progression has been established in many cancers. However, recent studies indicated aberrantly hypermethylated genes in multiple cancers are ...
ORGANISM(S): Homo sapiens 
2014-07-01 | E-GEOD-43094 | biostudies-arrayexpress
TranscriptomicsProfiling of Human Adipose Tissue and Effect of Sibutramine on Gene Expression
We analyzed the expression of 23,653 transcripts in the adipose tissue of 19 individuals treated with Sibutramine Keywords: sibutramine effect 157 adipose tissue samples from 19 individuals treated with sibutramin as well as placebo were profiled for gene expression.
ORGANISM(S): Homo sapiens 
2010-06-24 | E-GEOD-10545 | biostudies-arrayexpress
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