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TranscriptomicsEffect of BMP4 and noggin on gene expression in murine R1 ES cells
To confirm that the SMAD1/5- and SMAD4-associated genes are direct transcriptional regulators in mESCs in response to BMP, we treated undifferentiated R1 ES cells with BMP4 or with the BMP4 antagonist noggin, which can inhibit BMP signaling effectively for 4 h. Undifferentiated R1 ES cells were trea...
ORGANISM(S): Mus musculus 
2010-03-07 | E-GEOD-20527 | biostudies-arrayexpress
TranscriptomicsCopy number variation profiling of gastric tissues: Cancer Samples vs. Matched Adjacent Noncancerous Samples
Copy number variation profiling of gastric tissues comparing gastric cancer tissues with matched adjacent noncancerous tissues. Goal was to determine the effects of chromosomal imbalances on gene expression and carcinogenesis or progression. 27 pairs of gastric tissues: gastric cancer tissues vs. ma...
ORGANISM(S): Homo sapiens 
2012-05-22 | E-GEOD-33428 | biostudies-arrayexpress
TranscriptomicsAnalysis of Rice microRNAs Expression under Drought Stress
We used this microarray to monitor rice miRNA expression profile under osmotic stress. Most of rice miRNAs have no significant change. miR-169f showed osmotic-responsive up-regulation. However, the others members of miR-169 family displays no responses to the osmotic stress. Keywords: microRNA,rice,...
ORGANISM(S): Oryza sativa 
2010-06-11 | E-GEOD-5986 | biostudies-arrayexpress
TranscriptomicsExpression data from gastric tissues: Cancer Samples vs. Matched Adjacent Noncancerous Samples
To elucidate gene expression associated with copy number changes, we performed a genome-wide copy number and expression microarray analysis of 25 pairs of gastric tissues. 25 pairs of gastric tissues: gastric cancer tissues vs. matched adjacent noncancerous tissues.
ORGANISM(S): Homo sapiens 
2012-05-22 | E-GEOD-33335 | biostudies-arrayexpress
TranscriptomicsPathways identified by toxicogenomics analysis reveal the size and dose independency of silica particles-induced toxicity in mice.
Understanding the interactions of nanostructures with biological systems is essential to nanotoxicological research. Using a microarray-based toxicogenomics approach at early stage, this study investigated the relationship between particle size and toxicity of silica particles (SP) with diameters of...
ORGANISM(S): Mus musculus 
2011-07-31 | E-GEOD-30861 | biostudies-arrayexpress
TranscriptomicsGenome-wide expression analysis in Down syndrome: dynamic variation and insight into immunodeficiency
Down syndrome (DS) is caused by triplication of Human chromosome 21 (Hsa21) and associated with an array of deleterious phenotypes, including mental retardation, heart defects and immunodeficiency. Spatio-temporal patterns of genome-wide expression are critical to the understanding of DS. We used a ...
ORGANISM(S): Homo sapiens 
2012-02-10 | E-GEOD-35665 | biostudies-arrayexpress
TranscriptomicsExpression profiling of aging liver in low-fat diet mice
Dietary interventions are effective ways to extend or shorten lifespan. By examining midlife hepatic gene expressions in mice under different dietary conditions, which resulted in different lifespans and aging-related phenotypes, we were able to identify genes and pathways that modulate the aging pr...
ORGANISM(S): Mus musculus 
2012-03-27 | E-GEOD-36836 | biostudies-arrayexpress
TranscriptomicsExpression profiling of the effect of high-fat diet, low-fat diet, CR and exercise on mice liver
Dietary interventions are effective ways to extend or shorten lifespan. By examining midlife hepatic gene expressions in mice under different dietary conditions, which resulted in different lifespans and aging-related phenotypes, we were able to identify genes and pathways that modulate the aging pr...
ORGANISM(S): Mus musculus 
2012-03-27 | E-GEOD-36838 | biostudies-arrayexpress
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