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TranscriptomicsFoxOs are lineage-restricted redundant tumor suppressors and regulate endothelial cell homeostasis.
Activated phosphoinositide 3-kinase (PI3K)-AKT signaling appears to be an obligate event in the development of cancer. The highly related members of the mammalian FoxO transcription factor family, FoxO1, FoxO3, and FoxO4, represent one of several effector arms of PI3K-AKT signaling, prompting geneti...
ORGANISM(S): Mus musculus 
2011-03-16 | E-GEOD-27932 | biostudies-arrayexpress
UnknownSafety and immunogenicity of a novel therapeutic DNA vaccine encoding chicken type II collagen for rheumatoid arthritis in normal rats.
Not available
S-EPMC5054790 | biostudies-literature
UnknownEvaluation of humoral and cellular immune responses to a DNA vaccine encoding chicken type II collagen for rheumatoid arthritis in normal rats.
Not available
S-EPMC4514235 | biostudies-literature
UnknownMultiomics reveals microbial metabolites as key actors in intestinal fibrosis in Crohn's disease
Not available
S-SCDT-10_1038-S44321-024-00129-8 | biostudies-other
TranscriptomicsGene expression analysis of induced pluripotent stem cells from aneuploid chromosomal syndromes
Background:Human aneuploidy is the leading cause of early pregnancy loss, mental retardation, and multiple congenital anomalies. Due to the high mortality associated with aneuploidy, the pathophysiological mechanisms of aneuploidy syndrome remain largely unknown. Previous studies focused mostly on w...
ORGANISM(S): Homo sapiens 
2013-09-24 | E-GEOD-49247 | biostudies-arrayexpress
MetabolomicsClinical features and Multiomics Profiles Indicate Coagulation and Platelet Dysfunction as Key Pathological Pathways in COVID-19 Viral Sepsis
Background: The role of viral infections as a mediator of systemic immune dysfunction leading to sepsis has received limited attention compared to the bacterial pathogens. The COVID-19 pandemic and the increased cases of sepsis in the absence of known bacterial pathogens have highlighted the clinica...
2025-12-05 | MTBLS9664 | MetaboLights
ProteomicsIn-vivo crosslinking based affinity purification-mass spectrometry for targeting intracellular protein-protein interactions
Comprehensive interactome analysis of targeted proteins is of great significance to understand how pro-teins work together for functional regulation. Until now, affinity purification strategy with mass spec-trometry (AP-MS) has been recognized as the most widely used technique for studying protein-p...
ORGANISM(S): Homo Sapiens 
2022-12-01 | PXD038473 |
ProteomicsClinical features and Multiomics Profiles Indicate Coagulation and Platelet Dysfunction as Key Pathological Pathways in COVID-19 Viral Sepsis
Background: The role of viral infections as a mediator of systemic immune dysfunction leading to sepsis has received limited attention compared to the bacterial pathogens. The COVID-19 pandemic and the increased cases of sepsis in the absence of known bacterial pathogens have highlighted the clinica...
ORGANISM(S): Homo Sapiens 
2024-03-03 | PXD050303 |
ProteomicsA global multi-regional proteomic map of the human cerebral cortex
In this study, four groups of the iTRAQ quantification experiment using 2D-LC-MS/MS analysis, one group of the label-free quantification experiment using 2D-LC-MS/MS analysis, one group of the PRM quantification experiment of the human brain tissue were included. Therefore, six subprojects are incl...
ORGANISM(S): Homo Sapiens 
2021-03-09 | PXD024613 |
UnknownClosed Or Open after Source Control Laparotomy for Severe Complicated Intra-Abdominal Sepsis (the COOL trial): study protocol for a randomized controlled trial.
Not available
S-EPMC6015449 | biostudies-literature
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