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ProteomicsQuantitative Site-specific Chemoproteomic Profiling of Protein Lipoylation
Protein lipoylation is an evolutionarily conserved post-translational modification (PTM) from prokaryotes and eukary-otes. Lipoylation is known to contribute to several human diseases including metabolic disorders, cancer and Alz-heimer’s disease. While individual lipoylated proteins have been bioch...
ORGANISM(S): Homo Sapiens Escherichia Coli 
2022-02-05 | PXD031466 |
ProteomicsLysargiNase coupled with trypsin digestion enhanced the identification of protein ubiquitination sites
We used LysargiNase to enhance the identification of ubiquitinated sites
ORGANISM(S): Saccharomyces Cerevisiae 
2018-07-18 | PXD009060 |
ProteomicsUIM domain interacting proteins
we identified the UIM domain interacting protein though IP-MS, and quantified the related ubiquitin chains
ORGANISM(S): Saccharomyces Cerevisiae 
2021-02-07 | PXD024048 |
ProteomicsLarge-scale profiling of unexpected tryptic cleaved sites at ubiquitinated lysines
Trypsin specifically cleaves the C-terminus of lysine and arginine residues and is assumed to fails to cleave ubiquitin-modified sites. Based on this perception, the irregularly-cleaved ubiquitinated peptides were often regarded as false positives and discarded in proteomic analysis. Interestingly, ...
ORGANISM(S): Homo Sapiens 
2023-01-10 | PXD039353 |
ProteomicsDiscovery of Itaconate-Mediated Lysine Acylation
Itaconate is an important anti-microbial and immunoregulatory metabolite involved in host-pathogen interactions. A key mechanistic action of itaconate is through the covalent modification of cysteine residues via Michael addition, resulting in “itaconation”. However, it is unclear whether itaconate ...
ORGANISM(S): Mus Musculus 
2023-02-28 | PXD040508 |
ProteomicsA simplified and efficient extracellular vesicles-based proteomics strategy for early diagnosis of colorectal cancer
In this work, we have developed a simplified, fast and efficient EVs-based proteomics strategy to enable biomarker discovery for early diagnosis of CRC. By covalent conjugation of an EV-targeting probe, DSPE, to agarose beads, we achieved one-step enrichment of EVs from plasma fluids in 10 minutes w...
ORGANISM(S): Homo Sapiens 
PXD054231 |
ProteomicsCDK5RAP3, a UFL1 substrate adaptor, is critical for liver development
Protein modification by ubiquitin and ubiquitin-like proteins (UBLs) regulates numerous biological functions. The UFM1 system, a novel UBL conjugation system, is implicated in mouse development and hematopoiesis. However, its broad biological functions and working mechanisms remain largely elusive. ...
ORGANISM(S): Mus Musculus 
2019-01-14 | PXD012340 |
ProteomicsReversible phosphorylation of Rpn1 regulates 26S proteasome assembly and function
The fundamental importance of the 26S proteasome in health and disease suggests that its function must be finely controlled, and yet our knowledge about proteasome regulation remains limited. Posttranslational modifications, especially phosphorylation, of proteasome subunits have been shown to impac...
ORGANISM(S): Homo Sapiens 
2019-12-08 | PXD016643 |
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