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TranscriptomicsGlobal analyses of endonucleolytic cleavage in mammals reveal expanded repertoires of cleavage-inducing small RNAs and their targets
In mammals, small RNAs are important players in post-transcriptional gene regulation. While their roles in mRNA destabilization and translational repression are well appreciated, their involvement in endonucleolytic cleavage of target RNAs is poorly understood. Very few microRNAs are known to guide ...
ORGANISM(S): Homo sapiens 
2016-03-16 | E-GEOD-68254 | biostudies-arrayexpress
TranscriptomicsGlobal analyses of endonucleolytic cleavage in mammals reveal expanded repertoires of cleavage-inducing small RNAs and their targets
In mammals, small RNAs are important players in post-transcriptional gene regulation. While their roles in mRNA destabilization and translational repression are well appreciated, their involvement in endonucleolytic cleavage of target RNAs is poorly understood. Very few microRNAs are known to guide ...
ORGANISM(S): Homo sapiens 
2016-03-16 | E-GEOD-68244 | biostudies-arrayexpress
TranscriptomicsGlobal analyses of endonucleolytic cleavage in mammals reveal expanded repertoires of cleavage-inducing small RNAs and their targets
In mammals, small RNAs are important players in post-transcriptional gene regulation. While their roles in mRNA destabilization and translational repression are well appreciated, their involvement in endonucleolytic cleavage of target RNAs is poorly understood. Very few microRNAs are known to guide ...
ORGANISM(S): Homo sapiens 
2016-03-16 | E-GEOD-68253 | biostudies-arrayexpress
TranscriptomicsGlobal analyses of endonucleolytic cleavage in mammals reveal expanded repertoires of cleavage-inducing small RNAs and their targets
In mammals, small RNAs are important players in post-transcriptional gene regulation. While their roles in mRNA destabilization and translational repression are well appreciated, their involvement in endonucleolytic cleavage of target RNAs is poorly understood. Very few microRNAs are known to guide ...
ORGANISM(S): Mus musculus 
2016-03-16 | E-GEOD-68251 | biostudies-arrayexpress
TranscriptomicsCell-type restricted activity of hnRNPM promotes breast cancer metastasis via regulating alternative splicing
Tumor metastasis remains the major cause of cancer-related death, but its molecular basis is still not well understood. Here we uncovered a splicing-mediated pathway that is essential for breast cancer metastasis. We show that the RNA-binding protein hnRNPM promotes breast cancer metastasis by activ...
ORGANISM(S): Homo sapiens 
2014-06-03 | E-GEOD-57243 | biostudies-arrayexpress
TranscriptomicsIdentification of allele-specific alternative mRNA processing via transcriptome sequencing
Establishing the functional roles of genetic variants remains a significant challenge in the post-genomic era. Here, we present a method, allele-specific alternative mRNA processing (ASARP), to identify genetically influenced mRNA processing events using transcriptome sequencing (RNA-Seq) data. The ...
ORGANISM(S): Homo sapiens 
2012-03-29 | E-GEOD-29738 | biostudies-arrayexpress
TranscriptomicsIllumina mRNA-Seq of control and hnRNP H knockdown in 293T cells
Pre-mRNA splicing is regulated through combinatorial activity of RNA motifs including splice sites and splicing regulatory elements (SREs). Here, we show that the activity of a major class of mammalian SREs is highly sensitive to the strength of the adjacent 5' splice site (5'ss) sequence, and that...
ORGANISM(S): Homo sapiens 
2009-09-12 | E-GEOD-16642 | biostudies-arrayexpress
TranscriptomicsAnalysis of Transcriptome Complexity via RNA-Seq in Normal and Failing Murine Hearts
Accurate and comprehensive de novo transcriptome profiling in heart is a central issue to better understand cardiac physiology and diseases. Although significant progress has been made in genome-wide profiling for quantitative changes in cardiac gene expression, current knowledge offers limited insi...
ORGANISM(S): Mus musculus 
2011-10-18 | E-GEOD-29446 | biostudies-arrayexpress
TranscriptomicsHormones, Genes, and Athleticism: Effect of Androgens on the Avian Muscular Transcriptome
Male vertebrate social displays vary from physically simple to complex, with the latter involving exquisite motor command of the body and appendages. Studies of these displays have, in turn, provided substantial insight into neuromotor mechanisms. The neotropical golden-collared manakin (Manacus vit...
ORGANISM(S): Taeniopygia guttata 
2016-03-30 | E-GEOD-73660 | biostudies-arrayexpress
TranscriptomicsDecoding the Long Noncoding RNA during Cardiac Maturation: a Roadmap for Functional Discovery [lncRNA]
Cardiac maturation during perinatal transition of heart is critical for functional adaptation to hemodynamic load and nutrient environment. Perturbation in this process has major implications in congenital heart defects (CHDs). Transcriptome programming during perinatal stages is important informati...
ORGANISM(S): Mus musculus 
2016-08-20 | E-GEOD-85726 | biostudies-arrayexpress
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