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UnknownUnexpected mutations occurred in CRISPR/Cas9 edited Drosophila analyzed by deeply whole genomic sequencing.
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S-EPMC11002691 | biostudies-literature
ProteomicsA causal coding variant regulating alternative splicing of DOC2A at 16p.11.2 GWAS locus influences susceptibility to schizophrenia
Genome-wide association studies (GWASs) have reported numerous genetic variations associated with schizophrenia, but knowledge regarding relevant molecular mechanisms is limited. Many genes undergo sophisticated alternative splicing in the brain, and aberrations of this process may contribute to the...
ORGANISM(S): Mus Musculus 
2025-02-12 | PXD060711 |
ProteomicsHypothalamic malate dehydrogenase 2 (MDH2) modulates systemic glucose metabolism through oxytocin-mediated thermogenesis
Bariatric surgery improves hyperglycemia in obesity and type 2 diabetes (T2D), yet its central mechanisms remain unclear. Through cerebrospinal fluid proteomic profiling of rats, we identify reduced central malate dehydrogenase 2 (MDH2) levels that correlate with surgery-induced restoration of normo...
ORGANISM(S): Rattus Norvegicus 
2025-12-19 | PXD072275 |
ProteomicsSpatial-temporal protein interactome profiling via condensation enhanced crosslinking
MS data for the verification of metabolic incorporation of δ-photolysine, calculation for the crosslinking distance by DegP crosslinking, and the proteomics analysis for the dynamic direct interactome of NPM1 as well as the SG-specific interactomes of SARS-CoV-2 Nucleocapsid protein and YTHDF1/2.
ORGANISM(S): Homo Sapiens Escherichia Coli Severe Acute Respiratory Syndrome Coronavirus 2 
PXD052099 |
ProteomicsThe Quartet Data Portal: integration of community-wide resources for multiomics quality control (Proteomics)
The Project aims to provide resources for QC of multiple types of omic technologies and effective integration of diverse datasets from various scenarios. Large quantities of multi-omics materials, datasets, and best practice for their QC utilities were developed for whole process QC of large scale, ...
ORGANISM(S): Homo Sapiens 
2023-09-01 | PXD045065 |
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