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ProteomicsPlasma proteome profiling combined with clinical and genetic features reveals pathophysiological characteristics of β-thalassemia
The phenotype of β-thalassemia underlies multigene interactions, making clinical stratification complicated. An increasing number of genetic modifiers affecting the disease severity have been identified, but are still unable to meet the demand of precision diagnosis. Here, we systematically conducte...
ORGANISM(S): Homo Sapiens 
2022-03-10 | PXD032179 |
ProteomicsNovel Peptidomic Analysis Identifies Peptide Clusters with Potential for Disease Diagnosis and Dysregulated Proteolytic Processing
Mass spectrometry-based peptidomics provides a comprehensive approach to delineate the global proteolytic landscape of diseases and to identify potential biomarkers. However, current data analysis methods struggle to distill the peptidomic signatures of diseases. In this study, we conducted a peptid...
ORGANISM(S): Homo Sapiens 
2025-04-02 | PXD062496 |
Proteomicsβ-thalassemia plasma EVs proteomics
Here, we performed plasma extracellular vesicles (EVs) proteomics on 20 β-thalassemia major (TM) patients, 20 intermedia (TI) patients, and 20 healthy controls to explore the subgroup characteristics and the potential biomarkers. The proteome of paired plasma was analyzed in parallel to compare the ...
ORGANISM(S): Homo Sapiens 
2022-06-15 | PXD034548 |
ProteomicsThe Effect of Fatty Acids in Hepatic Insulin Resistance - Part 1
Monounsaturated fatty acid (MUFA) oleic acid (OA) has been reported to restore saturated fatty acid palmitic acid (PA)-induced hepatic insulin resistance (IR). However, the detailed molecular mechanism remains elusive. In addition, -3 polyunsaturated fatty acid (PUFA) such as Eicosapentaenoic acid (...
ORGANISM(S): Homo sapiens (Human) 
2019-07-11 | PXD012065 | Pride
Fatty acids  insulin resistance  pa  epa 
ProteomicsOptimized MeOH/MTBE-based Protein Precipitation and Lipid Removal Enables High Enrichment of Low Molecular Weight Peptides and Proteins from Human Plasma
Low molecular weight (LMW) peptides and proteins (LMWPs, < 30 kDa) in human plasma, serving as potential biomarkers or drug targets, are endowed with a wealth of biological and clinical research values. However, the extraction of LMW species is retarded by high-abundance proteins (HAPs) and therein ...
ORGANISM(S): Homo sapiens (Human) 
2020-07-07 | PXD016957 | Pride
Human Plasma Lc-ms/ms 
ProteomicsDeeply mining a universe of peptides Encoded by Long Noncoding RNAs
Long non-coding RNAs (lncRNAs) are generally defined as RNA transcripts longer than 200 nucleotides that are not translated into proteins. Recently, many small open reading frames (smORFs) embedded in lncRNA scripts have been verified to be able to encode functional polypeptides (namely lncRNA-SEPs ...
ORGANISM(S): Homo sapiens (Human) Mus musculus (Mouse) 
2023-05-06 | PXD016981 | Pride
Lncrna Mass spectrometry Smorf Enrichment Seps 
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