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UnknownDrought stress triggers proteomic changes involving lignin, flavonoids and fatty acids in tea plants.
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S-EPMC7511325 | biostudies-literature
ProteomicsProteomic profiling of the global protein changes of Neuro-2a cells treated with dFUS-E9C or control
We conducted unbiased mass spectrometric experiments to evaluate the specificity of dFUS-E9C. In these studies, Neuro-2a cells were treated with dFUS-E9C. The result revealed the detection of more than 5000 proteins, among which there was a notable degradation of FUS, confirming the targeted action ...
ORGANISM(S): Mus Musculus 
PXD062671 |
ProteomicsProteomic profiling of the global protein changes of Neuro-2a cells treated with siFUS or control
We conducted unbiased mass spectrometric experiments to evaluate the specificity of siFUS. In these studies, Neuro-2a cells were treated with siFUS. The result revealed the detection of more than 5000 proteins, among which there was a notable degradation of FUS, confirming the targeted action of siF...
ORGANISM(S): Mus Musculus 
PXD062670 |
TranscriptomicsAb initio identification of transcription start sites (TSSs) in the Rhesus macaque genome by histone modification and RNA-Seq
We addressed the lack of experimentally supported transcript annotations in the Rhesus macaque genome by ab initio identification of the transcription start sites (TSSs). We took advantage of histone H3 lysine 4 trimethylation (H3K4me3)'s ability to mark TSSs and the recently developed ChIP-Seq and ...
ORGANISM(S): Macaca mulatta 
2010-10-18 | E-GEOD-24538 | biostudies-arrayexpress
ProteomicsAnimal proteomics of depression
The amygdala plays a key role in the pathophysiology of depression, but the molecular mechanisms underlying amygdalar hyperactivity in depression remain unclear. In this study, we used a chronic mild stress (CMS) protocol to separate susceptible and insusceptible rat subgroups. Proteomes in the amyg...
ORGANISM(S): Rattus Norvegicus 
2019-01-15 | PXD044124 |
ProteomicsThiol metabolic heterogeneity in immune cells causes distinct molecular mechanisms of toxicity upon chronic lead exposure
Lead pollution is global, billions of people are chronically exposed to lead. Biological thiols are nature sequesters of lead. Human immune system is highly vulnerable to lead, unfortunately the underlying mechanism remains unknown. Using mass cytometry and mass spectrometry, we systematically ident...
ORGANISM(S): Homo Sapiens Mus Musculus 
2024-10-30 | PXD057344 |
ProteomicsThe p-MYH9/USP22/HIF-1α axis promotes lenvatinib resistance and cancer stemness in hepatocellular carcinoma
To understand the role of HIF1a in lenvatinib resistance, we conducted label-free quantitative proteome analysis in both control and lenvatinib resistance cell lines. This analysis revealed changes in the proteome due to the lenvatinib resistance, providing a valuable reference for further investiga...
ORGANISM(S): Homo Sapiens 
PXD055440 |
ProteomicsMulti-omic analysis reveals a CAF-stemness-governed classification in HCC liver transplant recipients
In patients with hepatocellular carcinoma (HCC) meeting the Milan criteria, liver transplantation (LT) is an effective therapy. This study aims to define the survival-related molecular biological features helping precisely identifying the patients with HCC beyond the Milan criteria who have acceptab...
ORGANISM(S): Homo Sapiens 
2025-02-24 | PXD061119 |
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