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TranscriptomicsGenome-wide location analysis of Dnmt3a-mediated epigenetic regulation in murine postnatal subventricular zone (SVZ) neural stem cells (NSCs) [NimbleGen]
DNA methylation at proximal promoters facilitates lineage restriction by silencing cell-type specific genes. However, euchromatic DNA methylation frequently occurs in regions outside promoters. The functions of such non-proximal promoter DNA methylation are unclear. Here we show that the de novo DNA...
ORGANISM(S): Mus musculus 
2010-06-25 | E-GEOD-22475 | biostudies-arrayexpress
UnknownNAD+-boosting agent nicotinamide mononucleotide potently improves mitochondria stress response in Alzheimer's disease via ATF4-dependent mitochondrial UPR.
Not available
S-EPMC11470026 | biostudies-literature
UnknownUpregulation of carbonic anhydrase 1 beneficial for depressive disorder.
Not available
S-EPMC10071615 | biostudies-literature
TranscriptomicsMurine postnatal subventricular zone (SVZ) neural stem cells (NSCs): Wild-type (WT) vs. Dnmt3a-null (KO)
Transcriptional profiling of mouse postnatal SVZ NSCs comparing WT NSCs with KO NSCs under proliferating/undifferentiated states as well as differentiating conditions. Goal was to determine Dnmt3a-dependent gene expression changes in postnatal SVZ NSCs Two-condition experiment with a dye-swap design...
ORGANISM(S): Mus musculus 
2010-07-29 | E-GEOD-22473 | biostudies-arrayexpress
ProteomicsMuscular lactate modulates phase transition-driven lactate body secretion to induce liver fibrosis during long-term overtraining
Exercise, as the fundamental therapy for metabolic diseases, often exhibits a dose-dependent fashion. However, the adverse effects of overtraining and underlying mechanisms remain unclear. Here, we show that long-term overtraining induces hepatic fibrosis in humans and mice. Mechanistically, excessi...
ORGANISM(S): Mus Musculus 
2024-05-21 | PXD052424 |
ProteomicsThe eWAT ubiquitinome of wild type mice and Mdm2 adipocyte-specific knock-in mice fed high-fat diet
The epididymal adipose tissue (eWAT) samples from wild type mice fed high-fat diet for 12 weeks (H_WT_E) and Mdm2 adipocyte-specific knock-in mice fed high-fat diet for 12 weeks (H_KI_E) were mixed separately, and subjected to ubiquitinome study by Label-free quantification and ubiquitination modifi...
ORGANISM(S): Mus Musculus 
2022-05-26 | PXD034127 |
ProteomicsRNA-Pull down and MS for Snhg3
To screen Snhg3-binding proteins using-RNA Pull down and MS
ORGANISM(S): Mus Musculus 
2023-01-17 | PXD039526 |
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