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MetabolomicsProduction of chain-extended cinnamoyl compounds by overexpressing two adjacent cluster-situated LuxR regulators in Streptomyces globisporus C-1027

Natural products from microorganisms are important sources for drug discovery. With the development of high-throughput sequencing technology and bioinformatics, a large amount of uncharacterized biosynthetic gene clusters (BGCs) in microorganisms have been found, which show the potential for nove...

2023-09-06 | MTBLS5152 | MetaboLights
MetabolomicsA metabolite-augmented FIB-4 machine learning panel achieves superior liver fibrosis staging in chronic liver disease

Accurate, non-invasive liver fibrosis detection is essential for chronic liver disease management, particularly with rising metabolic dysfunction-associated liver disease (MASLD) and chronic hepatitis B (CHB). While the Fibrosis-4 (FIB-4) index is widely used, its performance for advanced fibrosi...

2026-03-03 | MTBLS13946 | MetaboLights
ProteomicsCell Data-Indenpendent acquisition LC-MS/MS
In this work, a microwell-chip was prepared and modified. The microwell-chip was used for extraction of metabolites and subsequent protein digestion. Next, direct electrospray ionization mass spectrometry (ESI-MS) was adopted for metabolome identification and a data independent acquisition (DIA)-MS ...
ORGANISM(S): Homo sapiens (Human) Mus musculus (Mouse) 
2021-11-08 | PXD025634 | Pride
Dia Cell Lc-ms/ms 
MetabolomicsGNPS - LC-MS/MS metabolomes of fecal samples from zoo mammals
LC-MS/MS metabolomes of fecal samples from 101 individuals from 25 mammalian species, in collaboration with a zoo. DDA data for molecular networking. Collected on a qExactive and includes fecal samples, dietary samples, and quality control samples. See linked datasets: MSV000083859, https://www.ncbi...
ORGANISM(S): Mammalia (ncbitaxon:40674) 
MSV000086131 | GNPS
MetabolomicsGNPS - GC-MS metabolomes of fecal samples from zoo mammals
GC-MS single quad metabolomes of fecal samples from 101 individual animals from 25 mammalian species, in collaboration with a zoo. Includes fecal samples, dietary samples, and quality control samples. See linked datasets: MSV000086131, https://www.ncbi.nlm.nih.gov/bioproject/PRJNA693262/ Reference:...
ORGANISM(S): Mammalia (ncbitaxon:40674) 
2019-05-26 | MSV000083859 | GNPS
ProteomicsPhosphoproteome Analysis of Cerebrospinal Fluid Extracellular Vesicles in Primary Central Nervous System Lymphoma
Primary central nervous system lymphoma(PCNSL) is a rare extra-nodal non-Hodgkin’s lymphoma and accounts for 3%-4% of central nervous system tumors. Recent studies have highlighted the importance of cerebrospinal fluid derived extracellular vesicles in PCNSL. Extracellular vesicles(EVs) are nanoscal...
ORGANISM(S): Homo Sapiens (human) 
2023-07-12 | PXD040744 | JPOST Repository
MetabolomicsClinical efficacy of Yiqi Yangxue formula on knee osteoarthritis and unraveling therapeutic mechanism through plasma metabolites in rats.

OBJECTIVE: To observe the clinical efficacy and safety of Yiqi Yangxue formula (YQYXF) on knee osteoarthritis (KOA), and to explore the underlying therapeutic mechanism of YQYXF through endogenous differential metabolites and their related metabolic pathways.

METHOD...

2024-03-25 | MTBLS5667 | MetaboLights
ProteomicsNafamostat Mesilate Improves Sepsis Outcomes by Modulating Complement and Coagulation Pathways
Supporting data for: Nafamostat Mesilate Improves Sepsis Outcomes by Modulating Complement and Coagulation Pathways
ORGANISM(S): Homo Sapiens 
2026-02-24 | PXD074871 |
ProteomicsProteomic analysis in the study of the mitochondrial supercomplex assembly
Mitochondrial supercomplexes are functionally important, but how supercomplexes being assembled is not known. Mitochondrial Complex I has an important role in the assembly of supercomplex. In this study, we generated a series of cell model with shRNA mediated gene silencing or CRISPR-Cas9 gene knock...
ORGANISM(S): Homo Sapiens 
2021-01-08 | PXD023474 |
ProteomicsTandem proteomic and N-glycoproteomic analysis of extracellular vesicles
Extracellular vesicles (EVs) derived from diverse biofluids have emerged as promising noninvasive diagnostic biomarkers or signatures for various diseases. EV-associated N-glycoproteins are crucial for the biological functions of EVs and hold significant potential for disease diagnosis and prognosis...
ORGANISM(S): Homo Sapiens 
2024-11-05 | PXD057512 |
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