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ProteomicsThe H3K4 methyltransferase KMT2D is an essential cofactor for GATA1 at erythroid gene enhancers
Gene expression during cellular differentiation is coordinated by combinatorial interactions between transcription factors (TFs) and cofactors at promoters and enhancers. The “master TF” GATA1 coordinates gene transcription in a subset of hematopoietic lineages, including erythroid, megakaryocytic, ...
ORGANISM(S): Homo sapiens (Human) 
2026-04-10 | PXD076443 | Pride
Kmt2d  gata1  enhancer  transcription regulation  hematopoiesis  erythropoiesis  epigenetics 
UnknownTricistronic hepatitis C virus subgenomic replicon expressing double transgenes.
Not available
S-EPMC4277965 | biostudies-literature
UnknownPredicting pathological complete response following neoadjuvant chemoradiotherapy (nCRT) in patients with locally advanced rectal cancer using merged model integrating MRI-based radiomics and deep learning data.
Not available
S-EPMC11515279 | biostudies-literature
UnknownCase Report: Gefitinib in EGFR 19del recurrent aggressive fibromatosis.
Not available
S-EPMC12301188 | biostudies-literature
UnknownMeasurement and simulation of the relatively competitive advantages and weaknesses between economies based on bipartite graph theory.
Not available
S-EPMC5973568 | biostudies-literature
UnknownDesign, synthesis, and evaluation of novel arecoline-linked amino acid derivatives for insecticidal and antifungal activities.
Not available
S-EPMC11043403 | biostudies-literature
UnknownAssociation between Chloroplast and Mitochondrial DNA sequences in Chinese Prunus genotypes (Prunus persica, Prunus domestica, and Prunus avium).
Not available
S-EPMC4310034 | biostudies-literature
UnknownAcute Endoplasmic Reticulum Stress Induces Inflammation Reaction, Complement System Activation, and Lipid Metabolism Disorder of Piglet Livers: A Proteomic Approach.
Not available
S-EPMC9043290 | biostudies-literature
MetabolomicsCD73 inhibitor AB680 suppresses glioblastoma in mice by inhibiting purine metabolism and promoting P2RY12<sup>+</sup> microglia transformation.
CD73 (ecto-5'-nucleotidase) is a metabolic immune checkpoint that dephosphorylates AMP to produce adenosine. Adenosine plays a pivotal role in immunosuppressive tumor microenvironment (TME) through adenosine receptors expressed on various immune cells. AB680, a specific CD73 inhibitor, is currently ...
2025-08-04 | MTBLS11084 | MetaboLights
ProteomicsEPOP Restricts PRC2.1 Targeting to Chromatin by Directly Modulating Enzyme Complex Dimerization
Polycomb repressive complex 2 (PRC2) mediates developmental gene repression as two classes of holocomplexes, PRC2.1 and PRC2.2. EPOP is an accessory subunit specific to PRC2.1, which also contains PCL proteins. Unlike other accessory subunits that collectively facilitate PRC2 targeting, EPOP was i...
ORGANISM(S): Mus musculus (Mouse) 
2025-12-20 | PXD072233 | Pride
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