Sort   by:  
 Page size 
TranscriptomicsKMT2D haploinsufficiency in Kabuki Syndrome disrupts neuronal function through transcriptional and chromatin rewiring independent of H3K4-monomethylation
Kabuki Syndrome (KS) is a multisystemic rare disorder, characterized by growth delay, distinctive facial features, intellectual disability, and rarely autism spectrum disorder. This condition is mostly caused by de novo mutations of KMT2D, encoding a catalytic subunit of the COMPASS complex involved...
ORGANISM(S): Homo sapiens 
2022-12-25 | E-MTAB-10244 | biostudies-arrayexpress
ProteomicsThe H3K4 methyltransferase KMT2D is an essential cofactor for GATA1 at erythroid gene enhancers
Gene expression during cellular differentiation is coordinated by combinatorial interactions between transcription factors (TFs) and cofactors at promoters and enhancers. The “master TF” GATA1 coordinates gene transcription in a subset of hematopoietic lineages, including erythroid, megakaryocytic, ...
ORGANISM(S): Homo sapiens (Human) 
2026-04-10 | PXD076443 | Pride
Kmt2d  gata1  enhancer  transcription regulation  hematopoiesis  erythropoiesis  epigenetics 
TranscriptomicsAnalysis of transcriptome changes in Kmt2d deletion in cardiac mesoderm, anterior heart field precursors and cardiomyocytes
KMT2D is required in the cardiac mesoderm, anterior heart field precursors and cardiomyocytes. Kmt2d deletion in cardiac mesoderm (Mesp1Cre) is embryonic lethal at E10.5 and mutants have hypoplastic hearts; Kmt2d deletion in anterior heart field precursors (Mef2cAHF::Cre) deletion is embryonic letha...
ORGANISM(S): Mus musculus 
2015-11-04 | E-GEOD-74679 | biostudies-arrayexpress
GenomicsMLL4 (KMT2D) inactivating mutations lead to focal loss of H3K4me1/2 and deregulated gene expression in B cell lymphomas
We identified KMT2D target loci in OCI-LY7 by ChIPseq. KMT2D ChIPseq was carried out in the LY7 cell line (n=1).
ORGANISM(S): Homo sapiens 
2015-08-28 | E-GEOD-67314 | biostudies-arrayexpress
GenomicsRNA-seq of KMT2D Knockout and KMT2D WT melanoma in mice
RNA-seq of KMT2D Knockout and KMT2D WT melanoma in mice
PRJNA480453 | ENA
GenomicsGenome-wide maps of chromatin state in KMT2D Knockout and KMT2D WT melanoma in mice
Genome-wide maps of chromatin state in KMT2D Knockout and KMT2D WT melanoma in mice
PRJNA480444 | ENA
GenomicsChip-seq data for KMT2D HNSCC
Chip-seq data for KMT2D HNSCC
PRJNA769444 | ENA
GenomicsmRNA-seq data for KMT2D HNSCC
mRNA-seq data for KMT2D HNSCC
PRJNA769448 | ENA
ProteomicsKetogenic diet modifies ribosomal protein dysregulation in KMT2D Kabuki Syndrome
Kabuki syndrome (KS) is a genetic disorder caused by DNA mutations in KMT2D, a lysine methyltransferase that methylates histones and other proteins, and therefore modifies chromatin structure and subsequent gene expression. Ketones, derived from the ketogenic diet, are histone deacetylase inhibitors...
ORGANISM(S): Homo sapiens (Human) 
2024-06-23 | PXD050547 | Pride
Neurodevelopment Tmtpro Butyrate Hydrophilic interaction liquid chromatography Single-cell rna sequencing Lysine methyltransferase Epigenetic Tandem mass tag 
GenomicsKMT2D is essential for cerebellar granule cell differentiation
KMT2D is essential for cerebellar granule cell differentiation
PRJNA1184848 | ENA
Sort   by:  
 Page size