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ProteomicsDeep Succinylproteomics of Brain Tissues of Intracerebral Hemorrhage with inhibition of Toll-like receptor 4 signaling
The details of Toll-like receptor (TLR) 4 signaling affects protein succinylation in intracerebral hemorrhage (ICH) brains remains completely unclear. In this study, we constructed mice ICH models to investigate the changes in ICH-associated brain protein succinylation with the treatment of TLR4 ant...
ORGANISM(S): Mus musculus (Mouse) 
2021-11-03 | PXD025622 | Pride
Intracerebral hemorrhage  brain injury  succinylation  toll-like receptor 4 
ProteomicsSuccinylation profiles of brain injury after intracerebral hemorrhage
Protein posttranslational modifications (PTMs) has been shown to regulate biological processes of human diseases via expanding the genetic code and for regulating cellular pathophysiology, however, the system-wide changes at the PTMs levels in ICH brain remains little known. Given that succinylation...
ORGANISM(S): Mus musculus (Mouse) 
2021-10-29 | PXD025621 | Pride
Intracerebral hemorrhage  brain injury  succinylation 
ProteomicsAge-Dependent Changes in the Plasma Proteome of Healthy Adults
Human blood plasma is a complex which communicates with most parts of the body and reflects changes in the state of the organism, therefore identifying age-related biomarkers can help to predict and monitor age-related physiological decline and diseases, as well as to find new treatments for disease...
ORGANISM(S): Homo sapiens (Human) 
2020-10-19 | PXD016199 | Pride
Aging  healthy adults  plasma  proteomics  tmt-lc-ms/ms 
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