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ProteomicsDROSOPHILA FUS MUTANT PHENOTYPES ARE MEDIATED BY INCREASED XRP1 EXPRESSION LEADING TO GENE EXPRESSION DYSREGULATION
Several RNA-binding proteins (RBPs) are implicated in amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD), including the FET proteins FUS, TAF15 and EWSR1. Cabeza (caz) is the single Drosophila FET ortholog. Here, we identified Xrp1, a poorly characterized DNA-binding protein, as a...
ORGANISM(S): Drosophila melanogaster (Fruit fly) 
2018-09-06 | PXD008417 | Pride
Drosophila Fus At-hook motif Frontotemporal dementia Amyotrophic lateral sclerosis Gene expression regulation 
GenomicsXrp1 governs the stress response program to spliceosome dysfunction
Xrp1 governs the stress response program to spliceosome dysfunction
PRJNA880351 | ENA
ProteomicsRpS12-mediated induction of the Xrp1short isoform links ribosomal protein mutations to cell competition
Cell competition, the context-dependent cell elimination via short-range cell-cell interactions, was originally described in Drosophila, where heterozygous ribosomal protein (Rp+/-) mutant cells are outcompeted by wild-type neighbors. The transcription factor Xrp1 mediates most Rp+/- phenotypes, inc...
ORGANISM(S): Drosophila melanogaster (Fruit fly) 
2026-05-16 | PXD076715 | Pride
Xrp1 Minutes Drosophila Ribosomal mutants 
GenomicsmRNA-seq in Control, NAT10 KD, NAT10 and Xrp1 KD in Drosophila
mRNA-seq in Control, NAT10 KD, NAT10 and Xrp1 KD in Drosophila
PRJNA1272413 | ENA
UnknownXrp1 governs the stress response program to spliceosome dysfunction.
Not available
S-EPMC10954486 | biostudies-literature
TranscriptomicsXrp1 governs the stress response program to spliceosome dysfunction
We investigated the changes in gene expression in response to reduced levels of Ecdysoneless (Ecd), and the role of Xrp1 in induction of transcriptional changes upon loss of Ecd in the developing wing disc of Drosophila. To do this we utilized the GAL4/UAS system to express UAS-ecd-RNAi alone and in...
ORGANISM(S): Drosophila melanogaster 
2024-01-31 | GSE213298 | GEO
GenomicsRNA-seq analysis to assess transcriptional effects of Rp mutations in wing imaginal discs and their dependence on Xrp1
RNA-seq analysis to assess transcriptional effects of Rp mutations in wing imaginal discs and their dependence on Xrp1
PRJNA449346 | ENA
UnknownThe transcription factor Xrp1 orchestrates both reduced translation and cell competition upon defective ribosome assembly or function.
Not available
S-EPMC8933008 | biostudies-literature
TranscriptomicsRNA-seq analysis to assess transcriptional effects of Rp mutations in wing imaginal discs and their dependence on Xrp1
Since the putative transcription factor Xrp1 gene is required for many aspects of Rp+/- phenotypes, we sought to define what transcriptional changes occur in Rp+/- wing discs and their dependence on Xrp1. We identified 257 genes whose transcripts were significantly altered in the same direction in t...
ORGANISM(S): Drosophila melanogaster 
2018-08-20 | GSE112864 | GEO
UnknownXrp1 is a transcription factor required for cell competition-driven elimination of loser cells.
Not available
S-EPMC6286310 | biostudies-literature
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