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GenomicsTranscription factor Ebf1 regulates differentiation stage-specific signaling, proliferative expansion and survival of B cells [EBF1]
Transcription factor Ebf1 is an important determinant of early B lymphopoiesis. To gain insight into differentiation stage-specific functions of Ebf1, we conditionally inactivated Ebf1. We found that Ebf1 is required for proliferation, survival and signaling of pro-B cells and peripheral B cell su...
ORGANISM(S): Mus musculus 
2012-04-02 | E-GEOD-35910 | biostudies-arrayexpress
GenomicsTranscription factor Ebf1 regulates differentiation stage-specific signaling, proliferative expansion and survival of B cells
This SuperSeries is composed of the following subset Series: GSE35910: Transcription factor Ebf1 regulates differentiation stage-specific signaling, proliferative expansion and survival of B cells [EBF1] GSE35914: Transcription factor Ebf1 regulates differentiation stage-specific signaling, prolifer...
ORGANISM(S): Mus musculus 
2012-04-02 | E-GEOD-35915 | biostudies-arrayexpress
TranscriptomicsCell cyclin kinase inhibitor Cdkn2c regulates B cell homeostasis and function in the NZM2410-derived murine lupus susceptibility locus Sle2c1
Sle2c1 is an NZM2410-derived lupus susceptibility locus that induces an expansion of the B1a cell compartment. B1a cells have a repertoire enriched for autoreactivity, and an expansion of this B cell subset occurs in several mouse models of lupus. Here we showed that expression of Sle2c1 enhances NZ...
ORGANISM(S): Mus musculus 
2010-07-24 | E-GEOD-23114 | biostudies-arrayexpress
GenomicsDirect ChIP-bisulfite sequencing reveals a role of H3K27me3 mediating aberrant hypermethylation of promoter CpG islands in cancer cells (ChIP-BS)
The model describing that aberrant CpG island (CGI) methylation leads to transcription repression of tumor suppressor genes and thereby is implicated in tumor progression has been established in many cancers. However, recent studies indicated aberrantly hypermethylated genes in multiple cancers are ...
ORGANISM(S): Homo sapiens 
2014-07-01 | E-GEOD-43094 | biostudies-arrayexpress
TranscriptomicsExpression data from MDA-MB-231 cell line treated with Zoledronate, or Fluvastatin, or mock-treated control cells.
Statins and bisphosponates (BPs) are two distinct classes of isoprenoid pathway inhibitors targeting HMG-CoA reductase (upstream enzyme) and Farnesyl-pyrophospate synthase (downstream enzyme) respectively. Here we conducted a comparative study of two representatives of these classes, fluvastatin (Fl...
ORGANISM(S): Homo sapiens 
2012-01-01 | E-GEOD-33552 | biostudies-arrayexpress
TranscriptomicsCell type-specific induction of mRNA in human B cells and monocytes by IFN-beta
Compared to primary human monocytes in whole blood cultures, few B cells activated STAT1 in response to stimulation of 2000 IU/ml IFN-beta for 45 minutes. Because activation of STAT1 leads to apoptosis induction, we tested the hypothesis that less pro-apoptotic genes are induced in B cells as compa...
ORGANISM(S): Homo sapiens 
2010-10-20 | E-GEOD-23307 | biostudies-arrayexpress
GenomicsGenome-wide mapping of EBF1 binding sites in murine pre B-cells
Early B cell factor-1 (Ebf1), a transcription factor expressed in B cells, adipocytes and neuronal cells, has been identified as a determinant in the specification of the B cell lineage in which Ebf1 acts in a regulatory network with the transcription factors E2A and Pax5. To gain insight into the ...
ORGANISM(S): Mus musculus 
2010-05-06 | E-GEOD-19971 | biostudies-arrayexpress
TranscriptomicsmiRNA profiling of 36 cases of diffuse large B cell lymphoma
miRNA expression data from 36 cases of RCHOP treated DLBCL samples were correlated with clinical variables in order to find miRNA signatures related with outcome. Cases classified according to the cell of origin classsifer (Wright G, Tan B, Rosenwald A, Hurt EH, Wiestner A, Staudt LM. A gene express...
ORGANISM(S): Homo sapiens 
2011-08-01 | E-GEOD-21848 | biostudies-arrayexpress
TranscriptomicsmiRNA profiling of 29 cases of diffuse large B cell lymphoma
29 cases of RCHOP treated DLBCL were profiled for miRNA expression. Different integrated annalysis were performed, including mirNA differential expression between cases classified according to the COO signature (see later) and correlation tests between gene and miRNA expression. Cases classified acc...
ORGANISM(S): Homo sapiens 
2011-08-01 | E-GEOD-21847 | biostudies-arrayexpress
TranscriptomicsGene Expression Circulating B Lymphocytes for Smoking Females
B cells were found to be directly associated with the onset and development of many smoking-induced diseases. However, the in vivo molecular response of B cells underlying the female cigarette smoking remains unknown. Using the genome-wide Affymetrix HG-133A GeneChip® microarray, we compared the gen...
ORGANISM(S): Homo sapiens 
2009-12-25 | E-GEOD-18723 | biostudies-arrayexpress
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