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TranscriptomicsEpigenetic Repogramming by an Environmental Carcinogen Through Chromatin Domain Disruption [RNA-Seq]
Alterations in chromatin modifications, including DNA methylation and histone modification patterns, have been characterized under exposure of several environmental pollutants, including nickel. As with other carcinogenic metals, the mutagenic potential of nickel compounds is low and is not well cor...
ORGANISM(S): Homo sapiens 
2014-09-26 | E-GEOD-56052 | biostudies-arrayexpress
GenomicsEpigenetic Repogramming by an Environmental Carcinogen Through Chromatin Domain Disruption [ChIP-Seq]
Alterations in chromatin modifications, including DNA methylation and histone modification patterns, have been characterized under exposure of several environmental pollutants, including nickel. As with other carcinogenic metals, the mutagenic potential of nickel compounds is low and is not well cor...
ORGANISM(S): Homo sapiens 
2014-09-26 | E-GEOD-56051 | biostudies-arrayexpress
GenomicsDistinct roles of DNMT1-dependent and –independent methylation patterns in the genome of mouse ES cells
We generated base-resolution DNA methylomes of a series of DNMT knockout (KO) ES cells with improved coverage at highly repetitive elements. We find that DNMT1- and DNMT3a/3b-dependent activities actually work complementarily and simultaneously to establish symmetric CG methylation and CHH (H=A, T o...
ORGANISM(S): Mus musculus 
2015-05-27 | E-GEOD-61457 | biostudies-arrayexpress
GenomicsThe glucose-sensing transcription factor MLX promotes myogenesis via myokine signaling
Metabolic stress and changes in nutrient levels modulate many aspects of skeletal muscle function during aging and disease. Growth factors and cytokines secreted by skeletal muscle, known as myokines, are important signaling factors but it is largely unknown whether they modulate muscle growth and d...
ORGANISM(S): Mus musculus 
2015-11-11 | E-GEOD-74678 | biostudies-arrayexpress
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