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ProteomicsPrelamin A interacts with RIPK1 in ZMPSTE24-deficient cells
To understand the gain-of-toxicity of unprocessed prelamin A, we sought to identify the specific binding proteins of prelamin A that do not interact with mature lamin A. Because prelamin A is specifically localized to the nuclear envelope, we used ascorbate peroxidase 2 (APEX2)-based proximity label...
ORGANISM(S): Homo Sapiens 
2024-01-31 | PXD049033 |
ProteomicsSENP1 prevents steatohepatitis by suppressing RIPK1-driven apoptosis and inflammation
SENP1 deSUMOylates RIPK1 in TNF-R1 signaling complex (TNF-RSC), keeping RIPK1 in check. Loss of SENP1 leads to SUMOylation of RIPK1, which re-orchestrates TNF-RSC and modulates the ubiquitination patterns and activity of RIPK1.
ORGANISM(S): Mus Musculus 
2022-10-24 | PXD037648 |
ProteomicsRIPK1 senses S-adenosylmethionine depletion to drive cell death and inflammation
We show that RIPK1, a key mediator of cell death and inflammation, senses the abundance of methionine and its metabolite, S-adenosylmethionine (SAM), to dictate cell survival and death.
ORGANISM(S): Homo Sapiens 
2024-12-19 | PXD059023 |
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