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MetabolomicsLsr2, a novel cyclic di-GMP receptor, regulate the synthesis of keto-mycolic acid and control biofilm formation in mycobacteria

Cyclic di-GMP (c-di-GMP) is a well-known second messenger that plays a key role in many physiological processes in bacteria. The synthesis of lipids is essential for bacterial biofilm formation. However, whether c-di-GMP signaling modulates the synthesis of lipid and further regulates biofilm for...

2023-12-12 | MTBLS7053 | MetaboLights
TranscriptomicsExpression data from MDA-MB-231 cell line treated with Zoledronate, or Fluvastatin, or mock-treated control cells.
Statins and bisphosponates (BPs) are two distinct classes of isoprenoid pathway inhibitors targeting HMG-CoA reductase (upstream enzyme) and Farnesyl-pyrophospate synthase (downstream enzyme) respectively. Here we conducted a comparative study of two representatives of these classes, fluvastatin (Fl...
ORGANISM(S): Homo sapiens 
2012-01-01 | E-GEOD-33552 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of yeast using samples prepared with actinomycin D to exclude antisense artifacts
Recent transcription profiling studies have revealed an unanticipatedly large proportion of antisense transcription across eukaryotic and bacterial genomes. However, the extent and significance of antisense transcripts is controversial partly because experimental artifacts are suspected. Here, we pr...
ORGANISM(S): Saccharomyces cerevisiae 
2007-10-30 | E-TABM-361 | biostudies-arrayexpress
TranscriptomicsSAGE of cotton fibers and ovules.
Transcriptomes fiber and ovules were compared by applying serial analysis of gene expression (SAGE). Keywords: Tissue Comparison We constructed three SAGE libraries and sequenced 57321, 64188, and 69104 tags from fiber, Xu-142 ovule (ovule) and fl mutant ovules (fl) respectively of Upland Cotton, G...
ORGANISM(S): Gossypium hirsutum 
2007-02-17 | E-GEOD-6103 | biostudies-arrayexpress
ProteomicsParenchymal and Dyshorric Fibrillar Amyloid Pathology in the rTg-D Rat Model of Cerebral Amyloid Angiopathy Type-2
Whole brain tissue proteomics from rat models of cerebral small vessel disease and Alzheimer's disease, including the rTg-DI model of Cerebral Amyloid Angiopathy (CAA) Type-1, the rTg-D model of CAA Type-2 with both hemizygous and homozygous animals, and the TgSD-AD model of Alzheimer's Disease.
ORGANISM(S): Rattus norvegicus (Rat) 
2025-11-17 | PXD061304 | Pride
Cerebral amyloid angiopathy Preclinical model Alzheimer's disease Cerebral small vessel disease 
MetabolomicsMetabolomic analysis of riboswitch containing E. coli recombinant expression system
In this study we have employed metabolomics approaches to understand the metabolic effects of producing enhanced green fluorescent protein (eGFP) as a recombinant protein in Escherichia coli cells. This metabolic burden analysis was performed against a number of recombinant expression systems and co...
2017-11-16 | MTBLS393 | MetaboLights
UnknownDiethyl 4-(2-meth-oxy-phen-yl)-2,6-di-methyl-1,4-di-hydro-pyridine-3,5-di-carboxyl-ate.
Not available
S-EPMC3648309 | biostudies-literature
Unknownc-di-GMP inhibits rRNA methylation and impairs ribosome assembly in the presence of kanamycin
Not available
S-SCDT-10_1038-S44319-025-00377-W | biostudies-other
Unknownc-di-GMP inhibits rRNA methylation and impairs ribosome assembly in the presence of kanamycin.
Not available
S-EPMC11894153 | biostudies-literature
UnknownCyclic di-GMP integrates functionally divergent transcription factors into a regulation pathway for antioxidant defense.
Not available
S-EPMC6101608 | biostudies-literature
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