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GenomicGWAS of Preterm Birth

Preterm birth (PTB, born before 37 weeks of gestation) is a leading cause of neonatal mortality and post-natal morbidity. PTB affects one in nine all live births in the U.S. Notably, the highest rate of PTB occurs among African Americans (one in six). PTB is a complex trait, likely determined by ...

phs000332 | dbGaP
ProteomicsActivity-based sensing reveals elevated labile copper promotes liver aging via hepatic ALDH1A1 depletion
Oxidative stress plays a key role in aging and related diseases, including neurodegeneration, cancer, and organ failure. Copper (Cu), a redox-active metal ion, generates reactive oxygen species (ROS), and its dysregulation contributes to aging. Here, we develop activity-based imaging probes for the ...
ORGANISM(S): Mus Musculus (mouse) 
2025-01-16 | PXD059736 | JPOST Repository
TranscriptomicsWnt5A promotes an adaptive, senescent-like stress response, while continuing to drive invasion in melanoma cells.
We have previously shown that Wnt5A drives invasion in melanoma. We have also shown that Wnt5A promotes resistance to therapy designed to target the BRAF(V600E) mutation in melanoma. Here, we show that melanomas characterized by high levels of Wnt5A respond to therapeutic stress by increasing p21 an...
ORGANISM(S): Homo sapiens 
2015-08-07 | E-GEOD-50004 | biostudies-arrayexpress
ProteomicsSoluble SORLA enhances neurite outgrowth and regeneration through activation of EGFR and MAPK pathways
SORLA is a type I transmembrane component associated with Alzheimers disease (AD) risk. Although SORLA is abundantly expressed in neurons, physiological roles for SORLA remain yet unclear. Here, we show that cultured neurons overexpressing SORLA (SORLA TG) feature enhanced neurite length, and accele...
ORGANISM(S): Mus Musculus (ncbitaxon:10090) 
2020-05-12 | MSV000085400 | MassIVE
TranscriptomicsA sumoylation-dependent transcriptional subprogram is required for Myc-driven tumorigenesis
Myc is an oncogenic transcription factor frequently dysregulated in human cancer. To identify pathways supporting the Myc oncogenic program, we employed a genome-wide RNAi screen for Myc-synthetic-lethal (MySL) genes and uncovered a role for the SUMO-activating-enzyme (SAE1/2). Loss of SAE1/2 enzyma...
ORGANISM(S): Homo sapiens 
2011-12-08 | E-GEOD-34055 | biostudies-arrayexpress
TranscriptomicsExpression data from isogenic Pten WT mouse T-ALLs infected with MSCV Myr-AKT-IRES-mCherry or empty vector, treated with DBZ or DMSO
To explore the mechanisms downstream of NOTCH1 and PTEN in the control of leukemia cell growth, we performed expression profiling on NOTCH1 induced and Pten-positive T-ALL tumor cells infected with constitutively active AKT (myristoylated-AKT). Constitutive activation of AKT rescues the transcriptio...
ORGANISM(S): Mus musculus 
2015-08-31 | E-GEOD-71089 | biostudies-arrayexpress
TranscriptomicsExpression data from isogenic Pten WT or KO mouse T-ALLs treated with DBZ or DMSO
To investigate the underlying mechanisms mediating resistance to NOTCH inhibition in Pten-null T-ALL tumor cells we performed gene expression profiling of isogenic Pten-positive and Pten-deleted leukemia lymphoblasts after acute treatment with DBZ in vivo. This analysis revealed that, while direct N...
ORGANISM(S): Mus musculus 
2015-08-31 | E-GEOD-71087 | biostudies-arrayexpress
GenomicsQCMG_20130826 - samples
Analysis .bam files from HiSeq sequencing of Australian ICGC PDAC study samples, submitted 20130826
EGAD00001000660 | EGA
GenomicsQCMG20130201_pancreatic - samples
Sequencing data for Australian Pancreatic Cancer study submitted 20130102
EGAD00001000323 | EGA
GenomicsRNASeq_PACA-AU_Apr_2017 - samples
BAM outputs from RSEM (https://deweylab.github.io/RSEM/) analysis of RNASeq sequencing on HiSeq platform of tumour samples from 95 pancreatic adenocarcinoma cases.
EGAD00001003298 | EGA
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