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ProteomicsTMT-based proteomics analysis identifies RPLP1 as a key protein target in ursolic acid inhibition of colorectal cancer
Purpose: Ursolic Acid (UA), a triterpenoid extracted from Hedyotis Diffusa Willd. (HDW), is known for its anti-inflammatory, antioxidant, and antitumor effects. Nevertheless, the mechanisms underlying UA's anti-colorectal cancer (CRC) effects remain insufficiently understood. This study is aim to id...
ORGANISM(S): Homo sapiens (Human) 
2026-02-09 | PXD063684 | Pride
Colorectal cancer  hedyotis diffusa willd  ursolic acid  rplp1  tandem mass tags 
ProteomicsIntegrated Proteomic and Multi-Omic Characterizations of the Synapse Reveal RNA Processing Factors and Ubiquitin Ligases Associated with Neurodevelopmental Disorders
The molecular composition of the excitatory synapse is incompletely defined due to its dynamic nature across developmental stages and neuronal populations. To address this gap, we apply proteomic mass spectrometry to characterize the synapse in multiple biological models including the fetal human br...
ORGANISM(S): Homo sapiens (Human) Mus musculus (Mouse) 
2026-03-09 | PXD020933 | Pride
Induced neurons Synaptic Fetal brain Psd 
UnknownExtracting the femtometer structure of strange baryons using the vacuum polarization effect.
Not available
S-EPMC11470094 | biostudies-literature
UnknownProbing CP symmetry and weak phases with entangled double-strange baryons.
Not available
S-EPMC9159954 | biostudies-literature
UnknownGenome-wide association studies identify 137 genetic loci for DNA methylation biomarkers of aging.
Not available
S-EPMC8243879 | biostudies-literature
UnknownPrognostic evaluation of quick sequential organ failure assessment score in ICU patients with sepsis across different income settings.
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S-EPMC10804657 | biostudies-literature
UnknownA statistical framework for multi-trait rare variant analysis in large-scale whole-genome sequencing studies.
Not available
S-EPMC11981678 | biostudies-literature
UnknownPowerful, scalable and resource-efficient meta-analysis of rare variant associations in large whole genome sequencing studies.
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S-EPMC10084891 | biostudies-literature
UnknownWhole genome sequence analysis of low-density lipoprotein cholesterol across 246 K individuals.
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S-EPMC12418676 | biostudies-literature
UnknownDynamic incorporation of multiple in silico functional annotations empowers rare variant association analysis of large whole-genome sequencing studies at scale.
Not available
S-EPMC7483769 | biostudies-literature
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