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TranscriptomicsImproved transcription and translation with L-leucine stimulation of mTORC1
Roberts syndrome (RBS) is a human developmental disorder caused by mutations in the cohesin acetyltransferase ESCO2. We previously reported that mTORC1 was inhibited and overall translation was reduced in RBS cells. Treatment of RBS cells with L-leucine partially rescued mTOR function and protein sy...
ORGANISM(S): Homo sapiens 
2016-01-15 | E-GEOD-64962 | biostudies-arrayexpress
TranscriptomicsExpression data from MDA-MB-231 cell line treated with Zoledronate, or Fluvastatin, or mock-treated control cells.
Statins and bisphosponates (BPs) are two distinct classes of isoprenoid pathway inhibitors targeting HMG-CoA reductase (upstream enzyme) and Farnesyl-pyrophospate synthase (downstream enzyme) respectively. Here we conducted a comparative study of two representatives of these classes, fluvastatin (Fl...
ORGANISM(S): Homo sapiens 
2012-01-01 | E-GEOD-33552 | biostudies-arrayexpress
TranscriptomicsSenescence-associated lncRNAs: senescence-associated long noncoding RNAs.
Noncoding RNAs include small transcripts, such as microRNAs and piwi-interacting RNAs, and a wide range of long noncoding RNAs (lncRNAs). Although many lncRNAs have been identified, only a small number of lncRNAs have been characterized functionally. Here, we sought to identify lncRNAs differentiall...
ORGANISM(S): Homo sapiens 
2016-02-08 | E-GEOD-77675 | biostudies-arrayexpress
TranscriptomicsSystematically characterizing dysfunctional long intergenic non-coding RNAs in multiple brain regions of major psychosis
Schizophrenia (SZ) and bipolar disorder (BD) are severe neuropsychiatric disorders with serious impact on patients, together termed major psychosis. Recently, long intergenic non-coding RNAs (lincRNAs) were reported to play important roles in mental diseases. However, little was known about their mo...
ORGANISM(S): Homo sapiens 
2016-09-01 | E-GEOD-78936 | biostudies-arrayexpress
TranscriptomicsIdentification of long ncRNAs using RNA-seq in Arabidopsis
We profiled Arabidopsis transcriptom using RNA-seq. Each RNA library yielded 223-250 million 101-bp single-end reads (235M on average). Using Tophat and Cufflinks, 30,199~30,650 assembled transcripts were identified in each of 4 samples. Of them, 1340 ones were derived from intergenic regions includ...
ORGANISM(S): Arabidopsis thaliana 
2012-08-23 | E-GEOD-38612 | biostudies-arrayexpress
MetabolomicsA next-generation yeast chassis: comprehensive characterization of a robust fast-growing Saccharomyces cerevisiae

Robust and efficient hosts are necessary to facilitate advances in biotechnology. We unveil Saccharomyces cerevisiae strain XP as a promising new microbial chassis owing to its high growth rate and robustness. This strain has a doubling time of 48.2 min, which is 12.8 min faster than the...

2024-09-26 | MTBLS7328 | MetaboLights
TranscriptomicsMapping of INS promoter interactions reveals its role in long-range regulation of SYT8 transcription
Insulin (INS) synthesis and secretion from pancreatic M-NM-2 cells are tightly regulated; their deregulation causes diabetes. Here we map INS-associated loci in human pancreatic islets by 4C and 3C techniques and show that the INS gene physically interacts with the SYT8 gene, located over 300 kb ...
ORGANISM(S): Homo sapiens 
2011-02-22 | E-GEOD-25862 | biostudies-arrayexpress
TranscriptomicsLong noncoding RNAs expression patterns associated with chemo response to cisplatin based chemotherapy in lung squamous cell carcinoma patients
There is large variability among lung squamous cell carcinoma (SCC) patients in response to treatment with cisplatin based chemotherapy. LncRNAs is potentional a new type of predictive marker that can identify subgroups of patients who benefit from chemotherapy and it will have great value for treat...
ORGANISM(S): Homo sapiens 
2015-05-18 | E-GEOD-59245 | biostudies-arrayexpress
MetabolomicsRed-Fleshed Apple Anthocyanin Extracts Attenuate Male Reproductive System Dysfunction Caused by Busulfan in Mice (Mouse blood plasma; UPLC-MS/MS assays)

In this research, we analyzed the effect of oral administration of red-fleshed apple anthocyanin extract (RAAE) on busulfan-treated mice. At first, we showed that the most abundant component in RAAE was cyanidin 3-O-galactoside. To determine the effect of RAAE, mice were divided into control and ...

2021-06-07 | MTBLS2782 | MetaboLights
TranscriptomicsA genomic approach to bud mutation in sweet orange (Citrus sinensis L. Osbeck) fruit
Bud mutations arise often in citrus. The selection of mutants is one of the most important breeding methods in citrus. However, the molecular bases of bud mutation have rarely been studied. To identify the potential important or novel genes involved in bud mutation, different transcriptomic techniqu...
ORGANISM(S): Citrus sinensis 
2009-03-09 | E-GEOD-10729 | biostudies-arrayexpress
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