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MetabolomicsMechanical force promotes dimethylarginine dimethylaminohydrolase 1-mediated hydrolysis of the metabolite asymmetric dimethylarginine to enhance bone formation

Mechanical force is critical for the development and remodeling of bone. Here we report that mechanical force regulates the production of the metabolite asymmetric dimethylarginine (ADMA) via regulating the hydrolytic enzyme dimethylarginine dimethylaminohydrolase 1 (Ddah1) expression in osteobla...

2021-11-23 | MTBLS3725 | MetaboLights
UnknownLong- and short-run asymmetric impacts of climate variation on tuberculosis based on a time series study.
Not available
S-EPMC11464594 | biostudies-literature
UnknownPhosphatase PP2A is essential for TH17 differentiation.
Not available
S-EPMC6338861 | biostudies-literature
UnknownDeveloping an element system of hospital resilience to medical run in major emerging infectious diseases: a Delphi study.
Not available
S-EPMC12036257 | biostudies-literature
MetabolomicsProMetIS, deep phenotyping of mouse models by combined proteomics and metabolomics analysis

Genes are pleiotropic and getting a better knowledge of their function requires a comprehensive characterization of their mutants. Here, we generated multi-level data combining phenomic, proteomic and metabolomic acquisitions from plasma and liver tissues of two C57BL/6 N mouse models lacking the...

2021-09-01 | MTBLS1903 | MetaboLights
ProteomicsQuantitative O-GlcNAc analysis between wild type and sec-5 using SILIA (F2 R1 on QE-HF)
O-GlcNAcylation is a crucial post-translational modification of proteins observed in both plants and animals and plays a key role in growth and development. Plants have close OGT homologs, SECRET AGENT (SEC) and SPINDLY (SPY). In vitro, SEC has shown O-GlcNAc activity. Recently, a surprising discove...
ORGANISM(S): Arabidopsis thaliana (Mouse-ear cress) 
2024-05-22 | PXD044831 | Pride
Mass spectrometry O-glcnacylation Proteomics. Lectin weak affinity chromatography (lwac) 
MetabolomicsAnalysis of the human adult urinary metabolome variations with age, body mass index and gender by implementing a comprehensive workflow for univariate and OPLS statistical analyses. ('Sacurine' data set)

Urine metabolomics is widely used for biomarker research in the fields of medicine and toxicology. As a consequence, characterization of the variations of the urine metabolome under basal conditions becomes critical in order to avoid confounding effects in cohort studies. Such physiological infor...

2017-01-20 | MTBLS404 | MetaboLights
ProteomicsGlobal-scale enrichment and identification of O-GlcNAc modified peptides in Arabidopsis seedling (S1 Part 1: HCD and EThcD part from Eclipse)
O-GlcNAcylation is a crucial post-translational modification of proteins observed in both plants and animals and plays a key role in growth and development. However, our understanding of this PTM in plants lags behind animals. To bridge this knowledge gap, we performed a global scale enrichment of O...
ORGANISM(S): Arabidopsis thaliana (Mouse-ear cress) 
2024-05-21 | PXD044701 | Pride
Mass spectrometry O-glcnacylation Proteomics. Lectin weak affinity chromatography (lwac) 
ProteomicsQuantitative O-GlcNAc analysis between wild type and sec-5 using SILIA (F1 on Eclipse (EThcD)
O-GlcNAcylation is a crucial post-translational modification of proteins observed in both plants and animals and plays a key role in growth and development. Plants have close OGT homologs, SECRET AGENT (SEC) and SPINDLY (SPY). In vitro, SEC has shown O-GlcNAc activity. Recently, a surprising discove...
ORGANISM(S): Arabidopsis thaliana (Mouse-ear cress) 
2024-05-22 | PXD044832 | Pride
Mass spectrometry O-glcnacylation Proteomics. Lectin weak affinity chromatography (lwac) 
ProteomicsGlobal-scale enrichment and identification of O-GlcNAc modified peptides in Arabidopsis seedling (Part 1: HCD part from Eclipse)
O-GlcNAcylation is a crucial post-translational modification of proteins observed in both plants and animals and plays a key role in growth and development. However, our understanding of this PTM in plants lags behind animals. To bridge this knowledge gap, we performed a global scale enrichment of O...
ORGANISM(S): Arabidopsis thaliana (Mouse-ear cress) 
2026-07-29 | PXD044770 | Pride
Mass spectrometry O-glcnacylation Proteomics. Lectin weak affinity chromatography (lwac) 
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