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MetabolomicsFSCN1 as a new druggable target in adrenocortical carcinoma

Adrenocortical carcinoma (ACC) is a rare endocrine malignancy with a high risk of relapse and metastatisation. The actin-bundling protein fascin (FSCN1) is overexpressed in aggressive ACC and represents a reliable prognostic indicator. FSCN1 has been shown to synergize with the Rho/Rac GEF VAV2 i...

2023-03-20 | MTBLS6402 | MetaboLights
ProteomicsChronic exposure to low-level lipopolysaccharide dampens influenza-mediated inflammatory response via A20 and PPAR network
Influenza A virus (IAV) infection leads to severe inflammation, and while epithelial-driven inflammatory responses occur via activation of NF-B, the factors that modulate inflammation, particularly the negative regulators are less well-defined. In this study we show that A20 is a crucial molecular...
ORGANISM(S): Homo Sapiens 
2022-07-29 | PXD035611 |
ProteomicsThe H3K9me2-FOXG1-microRNA axis reduces cochlear hair cells damage by modulating autophagy in age-related hearing loss
Presbycusis, or age-related hearing loss (ARHL) [1], represents a major healthcare and social challenge in rapidly aging populations. ARHL significantly impairs communication, quality of life, and psychological well-being among older adults [2]. It typically manifests as a progressive, irreversible,...
ORGANISM(S): Mus Musculus 
2025-12-24 | PXD072393 |
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