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ProteomicsHepatic LONP1 Overexpression Ameliorates Hepatic Steatosis and Fibrosis in mice
Compared to control mice, liver-specific overexpression of LONP1 alleviated hepatic steatosis and attenuated fibrosis progression in MASH mice. Liver samples from three control mice injected with AAV-3×flag and fed a CDAHFD for 8 weeks were used as the control group, while those from three mice inje...
ORGANISM(S): Mus Musculus 
PXD069474 |
ProteomicsLeptin-deficient Mouse Serum TMT-label Discovery Proteomics Profiling
The aim of this project was to profile the proteome of mouse-derived serum in order to identify those that showed significant quantitative different proteins among leptin-deficient (db/db) mouse, the genetic non-alcoholic fatty liver disease (NAFLD) mouse model and their lean bks mouse group.
ORGANISM(S): Mus musculus (Mouse) 
2022-10-14 | PXD027937 | Pride
Tmt-lable Serum Lc-ms/ms 
ProteomicsLeptin-deficient Mouse Liver TMT-label Discovery Proteomics Profiling
The aim of this project was to profile the proteome of mouse-derived liver in order to identify those that showed significant quantitative different proteins among leptin-deficient (db/db) mouse, the genetic non-alcoholic fatty liver disease (NAFLD) mouse model and their lean BKS mouse group.
ORGANISM(S): Mus musculus (Mouse) 
2022-10-14 | PXD027938 | Pride
Liver Tmt-lable Lc-ms/ms 
ProteomicsPHACTR1, a coronary artery disease risk gene, drives endothelial dysfunction
Recent genome-wide association studies have identified PHACTR1 as a critical risk gene associated with polyvascular diseases. However, it remains elusive how PHACTR1 is involved in endothelial dysfunction. Here, we show that PHACTR1 triggers endothelial inflammation by activating NF-κB and disrupts ...
ORGANISM(S): Homo sapiens (Human) 
2022-08-16 | PXD034213 | Pride
Endothelial dysfunction  inflammation  phactr1  nitric oxide  innate immunity  coronary artery disease 
Proteomicsthe proteomics of IGFBP6 in endothelial cells (HUVECs)
To unravel the direct mechanism of the anti-inflammatory effects of IGFBP6 in ECs, we analysed HUVECs treated with either adenovirus-Flag-IGFBP6 (Ad-IGFBP6) or control adenovirus (Ad-NC). We precipitated IGFBP6 from overexpressed ECs followed by mass spectrometry.
ORGANISM(S): Homo Sapiens 
PXD052204 |
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