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UnknownAdjuvant sorafenib after heptectomy for Barcelona Clinic Liver Cancer-stage C hepatocellular carcinoma patients.

Aim

To investigate the efficacy and safety of adjuvant sorafenib after curative resection for patients with Barcelona Clinic Liver Cancer (BCLC)-stage C hepatocellular carcinoma (HCC).

Methods

Thirty-four HCC patients, classified as BCLC-stage C, received adjuvant sorafenib for high-r...
S-EPMC4910659 | biostudies-literature
UnknownEfficacy and safety of Xiangsha Liujunzi granules for functional dyspepsia: A multi-center randomized double-blind placebo-controlled clinical study.

Aim

To assess the efficacy and safety of a Chinese herbal medicine (CHM), Xiangsha Liujunzi granules, in the treatment of patients with functional dyspepsia (FD).

Methods

We performed a randomized, double-blind, placebo-controlled trial with patients from three centers. Two hundred an...
S-EPMC5558122 | biostudies-literature
UnknownAberrant alterations of the expressions and S-nitrosylation of calmodulin and the downstream factors in the brains of the rodents during scrapie infection.
The aberrant alterations of calmodulin (CaM) and its downstream substrates have been reported in some neurodegenerative diseases, but rarely described in prion disease. In this study, the potential changes of Ca2+/CaM and its associated agents in the brains of scrapie agent 263K-infected ...
S-EPMC5639865 | biostudies-literature
UnknownGlibenclamide alleviates β adrenergic receptor activation-induced cardiac inflammation.
β-Adrenergic receptor (β-AR) overactivation is a major pathological factor associated with cardiac diseases and mediates cardiac inflammatory injury. Glibenclamide has shown anti-inflammatory effects in previous research. However, it is unclear whether and how glibenclamide can alleviate cardiac inf...
S-EPMC9061800 | biostudies-literature
UnknownRemarkable increases of α1-antichymotrypsin in brain tissues of rodents during prion infection.
α1-Antichymotrypsin (α1-ACT) belongs to a kind of acute-phase inflammatory protein. Recently, such protein has been proved exist in the amyloid deposits which is the hallmark of Alzheimer's disease, but limitedly reported in prion disease. To estimate the change of α1-ACT during prion infection, the...
S-EPMC5639854 | biostudies-literature
GenomicsGenome wide association study of leprosy in Chinese population

Leprosy is a chronic infectious disease caused by Mycobacterium leprae (M. leprae). Due to M. leprae's narrow host range and an inability to be cultured in vitro, the biological investigation of this disease has been difficult. Host genetic factors have been ...

phs000217.v1.p1 | EGA
UnknownFoamy monocytes and atherogenesis in mice with combined hyperlipidemia and effects of antisense knockdown of apoCIII.
Hypertriglyceridemia (HTG), particularly in combined hyperlipidemia, increases risk for atherosclerotic cardiovascular disease, but the underlying mechanisms remain incompletely understood. We sought to determine contributions of circulating monocytes to atherosclerosis associated with HTG in combin...
S-EPMC11981816 | biostudies-literature
UnknownDesign principles of practical industrial-scale layered oxide cathodes with air/water stability for sustainable sodium-ion batteries.
Low-cost manganese-based oxides as promising cathodes for sodium-ion batteries still face significant challenges, including irreversible phase transition, air/water sensitivity, and low initial charge capacity. Herein, we precisely design a titanium-substituted Mn-based oxide cathode material with o...
S-EPMC12647261 | biostudies-literature
ProteomicsThe N-Myc-Responsive LncRNA MILIP Promotes Non-Homologous DNA End Joining to Alleviate Genotoxic Stress in Human Neuroblastoma
lncRNAMILIP promotes the NHEJ pathway through facilitating Ku70-Ku80 heterodimerization and is involved in the resistance to DNA-damaging therapeutics in neuroblastoma cells.
ORGANISM(S): Homo Sapiens 
2022-04-22 | PXD033372 |
ProteomicsThe pan-cancer lncRNA PLANE regulates an alternative splicing program and promotes cancer pathogenesis
Proteome analysis of Biotin- PLANE pull-down assays
ORGANISM(S): Homo Sapiens 
2020-11-26 | PXD022747 |
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