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ProteomicsBeclin 1 prevents ISG15-mediated cytokine storms to secure fetal hematopoiesis and survival
Proper control of inflammatory responses is essential for embryonic development, but the underlying mechanism is poorly understood. Here, we show that under physiological conditions, inactivation of ISG15, an inflammation amplifier, is associated with the interaction of Beclin 1 (Becn1), via its ECD...
ORGANISM(S): Mus musculus (Mouse) 
2025-05-07 | PXD057003 | Pride
Beclin 1 Mouse Fetal liver 
ProteomicsProteomic profiling and molecular reclassification of high-grade serous ovarian cancer
In this study, we performed a comprehensive proteomic analysis of 116 primary tumor tissues from HGSOC patients. Our findings offer valuable insights into HGSOC’s molecular landscape, which could inform future biological studies, drug discovery, and the development of targeted therapies.
ORGANISM(S): Homo Sapiens 
2026-02-12 | PXD074808 |
ProteomicsIdentification of the indisulam-regulated proteins in AGS cells using label-free quantitative proteomics
In this project, we used label-free quantitative proteomics to identify proteins that are differentially regulated by indisulam in the gastric cancer AGS cell line.
ORGANISM(S): Homo Sapiens 
2024-10-09 | PXD056709 |
ProteomicsHalo-WDR76_Purification_WDR76KObackground_MudPIT_wPTMs
Halo purification samples analyzed using Multidimentional Protein identification Technology (MudPIT) on Orbitrap Velos Elite. Baits Halo-WDR76. Purification was performed using whole cell extract from a stable cell line of 293FRT cells in WDR76 KO background. Control purification was performed on bl...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2021-02-11 | MSV000086849 | MassIVE
ProteomicsHalo-Control/WDR76/SPIN1/CBX5_purification_MudPIT_wPTMs
Halo purification samples analyzed using Multidimentional Protein identification Technology (MudPIT) on Orbitrap Velos Elite. Baits are Halo-WDR76, Halo-SPIN1, Halo-CBX5. The bait for Control Purification is Halo tag only. Purification for each bait was performed using whole cell extract from a stab...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2021-02-11 | MSV000086846 | MassIVE
ProteomicsHalo-WDR76_Purification_inWDR76KO_DSSO-XL-MS
Halo purified WDR76 from a stable cell line of 293FRT in WDR76 KO background. DSSO crosslinking performed in eluted samples. Data collected using ms1/ms2/ms3 method. Data searched using Proteomics Discoverer 2.4 with XlinkX.
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2021-02-09 | MSV000086828 | MassIVE
ProteomicsWDR76-SPIN1_SCAP-E2-XL_mzTab and mgf
SCAP-XL of Halo-WDR76 and SNAP-SPIN1 from stable cell line in WDR76 KO background. Serial Capture Affinity Purification (SCAP) was performed on whole cell extract of a stable cell line of 293FRT cells in WDR76 KO background. DSSO crosslinked in E2 sample. Data was acquired using a ms1/ms2/ms3 method...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2021-01-22 | MSV000086749 | MassIVE
ProteomicsWDR76-SPIN1_inWDR76KO_SCAP-MS_MudPIT
Serial Capture Affinity Purification (SCAP) samples analyzed using Multidimentional Protein identification Technology (MudPIT) on Orbitrap Velos Elite. Baits are SNAP-SPIN1 and Halo-WDR76. SNAP purification was performed first, then Halo purification was performed. SCAP was performed using whole cel...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2021-02-03 | MSV000086802 | MassIVE
ProteomicsAptamer-Mediated Proximity Labeling (ApMPL) for Spatially Resolved Deciphering Cell Membrane Protein Interactome
Cell membrane protein-protein interactions (PPIs) play pivotal roles in maintaining cellular homeostasis and physiological balance. Deciphering these interactions is crucial for understanding disease mechanisms and identifying therapeutic targets. While proximity labeling technologies have revolutio...
ORGANISM(S): Homo Sapiens 
2026-02-27 | PXD074981 |
ProteomicsEasySCP Unveils Extensive Liver Zonation at Single-cell Proteomics Resolution
The widespread adoption of single-cell proteomics (SCP) in biology has been limited by complex workflows and reliance on specialized instrumentation. Here we present EasySCP, a high-throughput and lossless method that integrates FACS-based single-cell sorting, an all-in-one, single-step digestion pr...
ORGANISM(S): Homo Sapiens Mus Musculus 
2025-10-30 | PXD070083 |
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