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ProteomicsThe crosstalk between CRL5 and APC/C E3 ligases regulates metastasis and chemo-sensitivity of cancer cells
Cullin-RING ligases (CRLs) and the anaphase-promoting complex/cyclosome (APC/C) are two major multi-subunit ubiquitin ligases essential for protein homeostasis. The underlying mechanism and biological consequence of their crosstalk remain elusive. Here, we employed tandem affinity purification follo...
ORGANISM(S): Homo sapiens (Human) 
2026-01-23 | PXD068961 | Pride
Cul5  apc11  neddylation  metastasis  chemo-sensitivity 
ProteomicsA Tissue-Specific Atlas of Mouse N-Glycoproteome
In this study, we employed StrucGP to generate the first high-resolution and site-specific N- glycoproteomic atlas across 24 diverse mouse tissues. This comprehensive dataset provides an unprecedented insight into the tissue-specific landscape of N-glycosylation, revealing how distinct glycan struct...
ORGANISM(S): Mus Musculus 
2025-05-07 | PXD063701 |
ProteomicsSite-specific N-glycoproteomics of aging mouse uterus tissues for benchmarking the StrucGAP analysis platform
This project presents the site-specific N-glycoproteomics dataset of aging mouse uterus tissues used to demonstrate and validate StrucGAP, a modular and scalable downstream analysis platform for glycoproteomics. Uterine samples were collected from 2- and 12-month-old C57BL/6 female mice (n = 15 per ...
ORGANISM(S): Mus Musculus 
2025-04-23 | PXD063260 |
ProteomicsQuantitative glycoproteomic, proteomic, and phosphoproteomic analysis of aged mouse ovary
In this work, we investigate the differences of site-specific N-glycosylation between young (2-month-old) and middle-aged (12-month-old) mouse ovarian tissues by integrating N-glycoproteomics and proteomic approaches with tandem mass tag (TMT) labeling.To identify signalling pathways associated with...
ORGANISM(S): Mus Musculus 
2024-09-14 | PXD056126 |
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