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ProteomicsNaringenin targets PI3K p85alpha to suppress PI3K/AKT signaling pathway and ameliorate disordered MMP-9 secretion in cigarette smoke extract-induced alveolar macrophages in vitro
Naringenin has demonstrated potential therapeutic effects against cigarette smoke-induced lung injury; however, its underlying mechanisms of regulating matrix metalloproteinase-9 (MMP-9) in alveolar macrophages remain unclear. Methods: The regulatory mechanisms of naringenin in cigarette smoke extra...
ORGANISM(S): Mus Musculus 
PXD063137 |
Proteomics[HPP-2.0] Phosphoproteome Profiling of uEV Reveals p-AQP2 and p-GSK3β as Potential Markers for Diabetic Nephropathy
We used ultra-high-sensitivity quantitative phosphoproteomics to identify phosphoproteins in urinary extracellular vesicles (uEVs) as potential biomarkers of DN. We detected 233 phosphopeptides within the uEVs, with 47 phosphoproteins exhibiting significant alterations in patients with DN compared t...
ORGANISM(S): Homo Sapiens 
2024-02-01 | PXD049107 |
Proteomics[HPP-2.0] Phosphoproteome Profiling of uEV Reveals p-AQP2 and p-GSK3β as Potential Markers for Diabetic Nephropathy-2
We used ultra-high-sensitivity quantitative phosphoproteomics to identify phosphoproteins in urinary extracellular vesicles (uEVs) as potential biomarkers of DN. We detected 233 phosphopeptides within the uEVs, with 47 phosphoproteins exhibiting significant alterations in patients with DN compared t...
ORGANISM(S): Homo Sapiens Bos Taurus 
2024-02-20 | PXD049714 |
ProteomicsProteomic analysis of extracellular vesicles from inflammatory fibroblasts in colorectal cancer lung metastasis
Pulmonary metastasis is a major cause of mortality in colorectal cancer (CRC), and the tumor microenvironment plays a critical role in metastatic progression. In particular, inflammatory fibroblasts have been implicated in shaping the metastatic niche; however, the molecular characteristics of their...
ORGANISM(S): Homo Sapiens 
2026-03-20 | PXD075933 |
ProteomicsThe ganglioside GM3 protects against abdominal aortic aneurysm by suppressing ferroptosis in vascular smooth muscle cells
This project provides insights into the role of ganglioside GM3 in the pathogenesis of abdominal aortic aneurysm (AAA).
ORGANISM(S): Homo Sapiens 
PXD045177 |
ProteomicsProteogenomic Characterization of Skull-base Chordoma
Skull-base chordoma (SBC) is a rare, aggressive bone cancer with a high recurrent rate. Genomic studies of SBC have improved our understanding of the disease’s biology. However, the molecular biological characteristics and the effective therapy of SBC remain unknown. Here, we carried out an integrat...
ORGANISM(S): Homo Sapiens 
PXD053550 |
ProteomicsProteomics of Hsc70-interacting Proteins
we compared the interacting proteins between Hsc70-WT and Hsc70-3KA using mass spectrometry to discover additional mediators of this process
ORGANISM(S): Homo Sapiens 
PXD051241 |
ProteomicsValidation experiment for pan-sarcoma
the data of validation experiments for pan-sarcoma projects
ORGANISM(S): Homo Sapiens 
2024-01-03 | PXD047429 |
ProteomicsProteomics and phosphoproteomics of pan-sarcoma
we establish a 272 Chinese STS patients cohort containing 12 sarcoma subtypes, well-differentiated liposarcoma (WDLPS), myxoid liposarcoma (MLPS), dedifferentiated liposarcoma (DDLPS), angiosarcoma (AS), undifferentiated sarcoma (UPS), myxofibrosarcoma (MFS), other fibroblastic/myofibroblastic tumor...
ORGANISM(S): Homo Sapiens 
2024-01-03 | PXD047297 |
ProteomicsSubcommissural organ (SCO) contributes to brain development via SCO-secreted peptides
To explore the role of SCO and its functional mechanism, we measure the SCO-derived peptide in CSF from C57B/6 mice and SCO-ablated mice.
ORGANISM(S): Mus Musculus 
2025-02-04 | PXD040641 |
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